[总花羊蹄甲茎对实验性肝损伤的保护作用]

[Protective effects of the stem of Berchemia racemosa Sieb. et Zucc. on experimental liver injuries].

作者信息

Sato N, Ohta S, Sakurai N, Kamogawa A, Inoue T, Shinoda M

机构信息

Faculty of Pharmaceutical Sciences, Hoshi University, Tokyo, Japan.

出版信息

Yakugaku Zasshi. 1995 Apr;115(4):295-306. doi: 10.1248/yakushi1947.115.4_295.

DOI:10.1248/yakushi1947.115.4_295

PMID:7602496

Abstract

The methanol extract and water extract from the stem of Berchemia racemosa (Rhamnaceae) showed protective effects on liver injuries induced by carbon tetrachloride (CCl4) and alpha-naphthylisothiocyanate (ANIT) in rats. The acetone extract of B. racemosa protected the liver injury induced by CCl4. One of the protective substances was identified as carpusin. Some fractions showed significant protective effects against the liver injury and cholestasis induced by ANIT.

摘要

鼠李科勾儿茶茎的甲醇提取物和水提取物对四氯化碳（CCl4）和α-萘异硫氰酸酯（ANIT）诱导的大鼠肝损伤具有保护作用。勾儿茶的丙酮提取物对CCl4诱导的肝损伤具有保护作用。其中一种保护物质被鉴定为卡普辛。一些组分对ANIT诱导的肝损伤和胆汁淤积具有显著的保护作用。