维生素 D 状况可能有助于健康受试者的血清胰岛素样生长因子 I 浓度。
Vitamin D status may contribute to serum insulin-like growth factor I concentrations in healthy subjects.
机构信息
Department of Endocrinology and Metabolism, University of Pisa, Via Paradisa 2, 56124 Pisa, Italy.
出版信息
J Endocrinol Invest. 2011 Sep;34(8):e200-3. doi: 10.3275/7228. Epub 2010 Jul 29.
OBJECTIVE
The aim of the study was to evaluate whether vitamin D [25-(OH) D3] status affects serum IGFI concentrations in healthy subjects.
DESIGN AND PATIENTS
Two hundred and forty-one consecutive healthy subjects were included in the present study.
MEASUREMENTS
Serum IGF-I and 25-(OH) D3 concentrations.
RESULTS
As expected, serum IGF-I concentrations progressively decreased with age (r=-0.55, p<0.0001); on the contrary, gender was not related to serum IGF-I levels. A positive relationship was identified between serum 25-(OH) D3 and IGF-I concentrations (r=0.33, p<0.0001); the 25-(OH) D3-dependent changes of serum IGF-I concentrations were observed also when subjects were divided on the basis of vitamin D deficiency; in fact, those with severe 25-(OH) D3 deficiency (<20 ng/ml) had lower (185 ± 83 μg/l) IGF-I values than those with mild-to absent 25-(OH) D3 deficit (225 ± 83 μg/l, p=0.0004).
CONCLUSIONS
25-(OH) D3 status may contribute to determine serum IGF-I levels in healthy population.
目的
本研究旨在评估维生素 D [25-(OH) D3] 状态是否会影响健康受试者的血清 IGFI 浓度。
设计和患者
本研究纳入了 241 例连续的健康受试者。
测量
血清 IGF-I 和 25-(OH) D3 浓度。
结果
正如预期的那样，血清 IGF-I 浓度随年龄逐渐降低（r=-0.55，p<0.0001）；相反，性别与血清 IGF-I 水平无关。血清 25-(OH) D3 与 IGF-I 浓度之间存在正相关关系（r=0.33，p<0.0001）；当根据维生素 D 缺乏情况对受试者进行分组时，也观察到了血清 IGF-I 浓度随 25-(OH) D3 变化的情况；事实上，那些有严重 25-(OH) D3 缺乏症（<20ng/ml）的患者（185±83μg/l）的 IGF-I 值低于那些有轻度至无 25-(OH) D3 缺乏症的患者（225±83μg/l，p=0.0004）。
结论
25-(OH) D3 状态可能有助于确定健康人群的血清 IGF-I 水平。
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