Immunosenescence Group, Department of Pathobiology and Medical and Forensic Biotechnologies, University of Palermo, Corso Tukory 211, 90134 Palermo, Italy.
Mediators Inflamm. 2010;2010:802078. doi: 10.1155/2010/802078. Epub 2010 Jul 1.
Obesity is an energy-rich condition associated with overnutrition, which impairs systemic metabolic homeostasis and elicits stress. It also activates an inflammatory process in metabolically active sites, such as white adipose tissue, liver, and immune cells. As consequence, increased circulating levels of proinflammatory cytokines, hormone-like molecules, and other inflammatory markers are induced. This determines a chronic active inflammatory condition, associated with the development of the obesity-related inflammatory diseases. This paper describes the role of adipose tissue and the biological effects of many adipokines in these diseases.
肥胖是一种与营养过剩相关的高能状态，会损害全身代谢稳态并引发应激。它还会在代谢活跃的部位（如白色脂肪组织、肝脏和免疫细胞）引发炎症过程。因此，会诱导循环中促炎细胞因子、激素样分子和其他炎症标志物水平升高。这决定了一种慢性活跃的炎症状态，与肥胖相关炎症性疾病的发生有关。本文描述了脂肪组织的作用以及许多脂肪因子在这些疾病中的生物学效应。
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