一种新的基于若丹明的铜离子化学传感器及其在活细胞中行为的研究。
A new rhodamine-based chemosensor for Cu2+ and the study of its behaviour in living cells.
机构信息
State Key Laboratory of Applied Organic Chemistry and College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, P. R. China.
出版信息
Dalton Trans. 2010 Sep 14;39(34):7894-6. doi: 10.1039/c0dt00606h. Epub 2010 Jul 30.
PMID:20672168
Abstract
A new rhodamine-based chemosensor (L1) was synthesized, and it exhibits high sensitivity and selectivity for the copper cation over other commonly coexistent metal ions in aqueous solution. Upon the addition of Cu(2+), the spirolactam ring of L1 was opened and a 1 : 1 metal-ligand complex was formed. Fluorescent imaging of Cu(2+) in living cells is also successfully demonstrated.
摘要
一种新型的基于罗丹明的化学传感器（L1）被合成，它在水溶液中对铜阳离子表现出了高于其他常见共存金属离子的高灵敏度和选择性。加入 Cu(2+)后，L1 的螺环酰胺环被打开，形成了 1:1 的金属-配体络合物。还成功地证明了 L1 在活细胞中对 Cu(2+)的荧光成像。
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