干扰素对2型单纯疱疹病毒诱导的生化转化的抑制作用。
Inhibition of herpes simplex virus type 2-induced biochemical transformation by interferon.
作者信息
Rapp F, Nishiyama Y
出版信息
J Virol. 1980 Jan;33(1):543-6. doi: 10.1128/JVI.33.1.543-546.1980.
Abstract
The effect of interferon on the biochemical transformation of thymidine kinase-deficient cells by UV-inactivated herpes simplex virus type 2 has been studied. Transformation was much less sensitive to the action of interferon than virus multiplication. However, the continuous presence of a high dose of interferon (2,000 U) inhibited transformation almost completely. Although we could not differentiate between the effect of interferon on fixation and expression of the virus thymidine kinase gene, data suggest that the inhibitory effect of interferon on transformation might be partially due to the suppression of virus thymidine kinase expression.
摘要
研究了干扰素对紫外线灭活的2型单纯疱疹病毒所致胸苷激酶缺陷细胞生化转化的影响。转化对干扰素作用的敏感性远低于病毒增殖。然而，高剂量干扰素（2000单位）的持续存在几乎完全抑制了转化。尽管我们无法区分干扰素对病毒胸苷激酶基因固定和表达的影响，但数据表明，干扰素对转化的抑制作用可能部分归因于病毒胸苷激酶表达的抑制。
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