Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Ophthalmology. 2010 Sep;117(9):1800-9, 1809.e1-2. doi: 10.1016/j.ophtha.2010.01.042. Epub 2010 Jul 29.
To compare pathologic changes in photoreceptors in eyes with resolved central serous chorioretinopathy (CSC) seen on high-resolution images obtained by adaptive optics scanning laser ophthalmoscopy (AO SLO) with visual acuity (VA) and findings on spectral-domain optical coherence tomography (SD OCT).
Observational case series.
Forty-five eyes of 38 patients with resolved CSC and 20 normal eyes of 20 volunteer subjects.
All patients underwent a full ophthalmologic examination, SD OCT, and imaging with an original prototype AO SLO system fabricated using liquid crystal-on-silicon technology.
Cone mosaic patterns and cone density on AO SLO images and VA in eyes with CSC.
In normal eyes, AO SLO images showed a regular photoreceptor mosaic pattern and average cone densities 0.2, 0.5, and 1.0 mm from the central fovea of 67,900, 33,320, and 14,450 cones/mm(2). In eyes with CSC, cone densities were significantly lower at each distance from the central fovea (P = 0.009 at 0.2 mm, P = 0.007 at 0.5 mm, and P = 0.004 at 1.0 mm), and 2 distinct cone mosaic patterns were seen. Group 1 CSC eyes had regular cone mosaic patterns with small dark regions. Group 2 CSC eyes had irregular mosaic patterns with large dark regions. Compared with group 1, group 2 had significantly lower average cone density and worse average logarithm of the minimum angle of resolution (logMAR) VA (P<0.001). Mean cone density in eyes with disruptions in the photoreceptor inner and outer segment (IS/OS) junction or in the intermediate line on SD OCT images was significantly lower than that in eyes with an intact IS/OS junction or intermediate line (P<0.001 for both). Cone density 0.2 mm from the central fovea correlated with logMAR VA and mean foveal thickness (1-mm diameter area) measured on SD OCT images (P<0.001 for both).
Adaptive optics SLO images showed abnormal cone mosaic patterns and reduced cone densities in eyes with resolved CSC, and these abnormalities were associated with VA loss, suggesting that AO SLO is a useful means to detect and measure cone abnormalities associated with VA loss in these eyes.
比较自适应光学扫描激光检眼镜（AO SLO）高分辨率图像所见已缓解的中心性浆液性脉络膜视网膜病变（CSC）患者的光感受器病理改变与视力（VA）和频域光学相干断层扫描（SD OCT）的结果。
观察性病例系列。
已缓解 CSC 的 38 例患者的 45 只眼和 20 名志愿受试者的 20 只正常眼。
所有患者均接受全面眼科检查、SD OCT 和使用基于液晶硅技术的原始原型 AO SLO 系统成像。
CSC 患者的 AO SLO 图像中的视锥细胞镶嵌模式和视锥细胞密度及 VA。
在正常眼中，AO SLO 图像显示出规则的光感受器镶嵌模式和距中心凹 0.2、0.5 和 1.0 mm 处的平均视锥细胞密度分别为 67900、33320 和 14450 个/mm²。CSC 眼中，距中心凹各距离的视锥细胞密度均显著降低（0.2 mm 时 P=0.009，0.5 mm 时 P=0.007，1.0 mm 时 P=0.004），并可见 2 种不同的视锥细胞镶嵌模式。CSC 组 1 眼的视锥细胞镶嵌模式规则，伴有小暗区。CSC 组 2 眼的视锥细胞镶嵌模式不规则，伴有大暗区。与组 1 相比，组 2 的平均视锥细胞密度显著降低，平均最小角分辨率对数视力（logMAR VA）更差（P<0.001）。SD OCT 图像上可见光感受器内节/外节（IS/OS）连接中断或中间线中断的眼的平均视锥细胞密度明显低于 IS/OS 连接完整或中间线完整的眼（均 P<0.001）。距中心凹 0.2 mm 处的视锥细胞密度与 SD OCT 图像上测量的 logMAR VA 和平均中心凹厚度（1 mm 直径区域）相关（均 P<0.001）。
已缓解 CSC 患者的 AO SLO 图像显示出异常的视锥细胞镶嵌模式和视锥细胞密度降低，这些异常与 VA 丧失有关，提示 AO SLO 是一种有用的方法，可用于检测和测量这些眼中与 VA 丧失相关的视锥细胞异常。
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