Unoki T
Jpn Circ J. 1978 Jul;42(7):855-64. doi: 10.1253/jcj.42.855.
Uremic patients on prolonged maintenance hemodialysis (hemodialysis patients) are at high risk for atherosclerotic cardiovascular complications. To investigate the serum lipoprotein (Lp) abnormalities in hemodialysis patients, high density Lp (HDL) concentration was determined using ultracentrifugal analysis and quantitative immunoelectrophoresis in 23 hemodialysis patients, 8 non-uremic hyperlipidemic subjects, and 12 normal subjects. Immunoreactive HDL as well as HDL-cholesterol (HDL-Ch) in hemodialysis patients was lower significantly than the level in patients with non-uremic hyperlipidemia or normolipidemic healthy persons. Taking the results of previous reports into counts, decrease in HDL and HDL-Ch seems to contribute to the development of dyslipoproteinemia (broad-midband lipoproteinemia; an accumulation of the intermediate Lp or the remnant Lps) in hemodialysis patients. The results of the present study suggest that protective function proposed by the previous workers of HDL against atherosclerosis may be operated by facilitating the elimination of the accumulated midband Lps.
接受长期维持性血液透析的尿毒症患者（血液透析患者）发生动脉粥样硬化性心血管并发症的风险很高。为了研究血液透析患者的血清脂蛋白（Lp）异常情况，我们采用超速离心分析法和定量免疫电泳法，对23例血液透析患者、8例非尿毒症高脂血症患者和12例正常受试者的高密度Lp（HDL）浓度进行了测定。血液透析患者的免疫反应性HDL以及HDL胆固醇（HDL-Ch）水平显著低于非尿毒症高脂血症患者或血脂正常的健康人。综合以往报告的结果来看，HDL和HDL-Ch的降低似乎促使血液透析患者发生了脂蛋白异常血症（宽中带脂蛋白血症；中间Lp或残余Lp的蓄积）。本研究结果提示，先前研究人员提出的HDL对动脉粥样硬化的保护作用，可能是通过促进清除蓄积的中带Lp来实现的。
