Institute of Neuroscience, Doctorate in Clinical Psychology, Newcastle University, Ridley Building, Newcastle upon Tyne NE17RU, UK.
J Affect Disord. 2011 Feb;128(3):291-8. doi: 10.1016/j.jad.2010.07.003. Epub 2010 Jul 31.
Bipolar disorders are often not recognized. Several screening tools have been developed, e.g., the Hypomania Checklist-32 (HCL-32) and the Mood Disorder Questionnaire (MDQ) to improve this situation. Whereas the German HCL-32 has been used in non-clinical samples, neither the HCL-32 nor the MDQ has been validated in German samples of mood-disordered patients. Additionally, hardly any prior study has included patients with non-mood disorders or has considered potential effects of comorbid conditions. Therefore the goal of this study was to test the validity of both scales in a diverse patient sample while also taking into account psychiatric comorbidity.
A multi-site study was conducted involving seven centers. Patients (n=488) completed the HCL-32 and MDQ and were independently interviewed with the Structured Clinical Interview for DSM (SCID).
Sensitivity for bipolar I was similar for HCL-32 and MDQ (.88 and .84) but slightly different for bipolar II (.90 and .83), specificity, however, was higher for MDQ. In general, a comorbid condition led to increased scores in both tools regardless of whether the primary diagnosis was bipolar or not. LIMITATIONS AND DISCUSSION: Although we included not just mood-disordered patients, detailed subgroup analyses for all diagnostic categories were not possible due to sample sizes. In summary, HCL-32 and MDQ seem fairly comparable in detecting bipolar disorders although their effectiveness depends on the goal of the screening, psychiatric comorbidity, and potentially the setting.
双相情感障碍常常未被识别。已经开发了几种筛查工具，例如，轻躁狂清单-32（HCL-32）和心境障碍问卷（MDQ），以改善这种情况。尽管德国的 HCL-32 已在非临床样本中使用，但 HCL-32 和 MDQ 均未在德国心境障碍患者样本中得到验证。此外，几乎没有任何先前的研究包括非心境障碍患者，也没有考虑潜在的合并症的影响。因此，本研究的目的是在考虑合并症的情况下，在多样化的患者样本中测试这两种量表的有效性。
进行了一项多中心研究，涉及七个中心。患者（n=488）完成了 HCL-32 和 MDQ，并由结构临床访谈 DSM（SCID）进行独立访谈。
HCL-32 和 MDQ 对双相 I 的敏感性相似（分别为 0.88 和 0.84），但对双相 II 的敏感性略有不同（分别为 0.90 和 0.83），然而，MDQ 的特异性更高。一般来说，无论原发性诊断是否为双相，合并症都会导致两种工具的分数增加。
尽管我们不仅包括心境障碍患者，但由于样本量，无法对所有诊断类别进行详细的亚组分析。总之，HCL-32 和 MDQ 在检测双相障碍方面似乎相当可比，尽管它们的有效性取决于筛查的目的、合并症和潜在的环境。
