Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Int J Psychiatry Clin Pract. 2012 Jun;16(2):132-7. doi: 10.3109/13651501.2011.644563. Epub 2012 Jan 2.
The sensitivity and specificity of the Chinese versions of the Hypomania Symptom Checklist-32 (HCL-32) and Mood Disorder Questionnaire (MDQ) for detecting bipolar disorder in Taiwan were explored in this study.
In total, 59 participants who were initially diagnosed with unipolar depression were recruited from an outpatient clinic and were screened for bipolar disorder using the HCL-32 and MDQ; each participant also underwent a diagnostic interview based on the Structured Clinical Interview for DSM-IV Axis disorder patients (SCID).
The results showed that the HCL-32 yielded the best combination of sensitivity (100%) and specificity (46.2%) at a cut-off point of 7/8, and the MDQ yielded the best combination of sensitivity (71.4%) and specificity (76.9%) at a cut-off point of 6/7.
The results of our study demonstrate that the HCL-32 and MDQ are of reasonable validity to distinguish between bipolar disorder and major depressive disorder. However small sample size may limit generalization of the results.
本研究旨在探讨中文版轻躁狂症状清单-32（HCL-32）和心境障碍问卷（MDQ）在中国台湾地区检测双相障碍的敏感性和特异性。
本研究共招募了 59 名最初被诊断为单相抑郁的门诊患者，使用 HCL-32 和 MDQ 对他们进行双相障碍筛查；每位患者还接受了基于 DSM-IV 轴障碍患者定式临床访谈（SCID）的诊断访谈。
结果显示，HCL-32 在截断值为 7/8 时具有最佳的敏感性（100%）和特异性（46.2%）组合，MDQ 在截断值为 6/7 时具有最佳的敏感性（71.4%）和特异性（76.9%）组合。
本研究结果表明，HCL-32 和 MDQ 具有合理的有效性，可以区分双相障碍和重度抑郁症。但是，小样本量可能限制了结果的推广。
