Department of Lipid Science and Traditional Foods, Central Food Technological Research Institute, Council of Scientific and Industrial Research, Mysore 570 020, India.
Prostaglandins Leukot Essent Fatty Acids. 2010 Sep;83(3):151-60. doi: 10.1016/j.plefa.2010.06.004. Epub 2010 Jul 31.
The present investigation was undertaken to study the effects of feeding a diet containing blended and interesterified fat to rats on thrombotic parameters such as platelet aggregation and eicosanoid levels in blood serum. Male Wistar rats were fed with a diet containing 10% fat from native; coconut oil (CNO), rice bran oil (RBO), sesame oil (SESO), blended; (CNO+RBO blend (B), CNO+SESO(B), or interesterified oils; CNO+RBO interesterified (I), CNO+SESO(I) for a period of 60 days. Rats given a diet containing blended oil of CNO+RBO(B) or CNO+SESO(B) showed a decrease in rate of ADP induced aggregation of platelets by 34% and 30%, respectively, compared to those fed with CNO. Aggregation induced by collagen was also reduced similarly in rats given blended or interesterified oils of CNO with RBO or SESO. Feeding interesterified oil CNO+RBO(I), and CNO+SESO(I) to rats also resulted in decrease in rate of ADP induced platelet aggregation by 37% and 34%, respectively, compared to rats fed with CNO. The prostacyclin/thromboxane ratio in serum was increased in rats fed with blended and interesterified oil compared to those fed with CNO. These results indicated that CNO when blended or interesterified with RBO or SESO exhibit antithrombotic effects as compared to the effect observed by feeding rats with CNO.
本研究旨在探讨饲粮中添加和酯交换脂肪对血小板聚集和血清中花生四烯酸水平等血栓形成参数的影响。雄性 Wistar 大鼠用含有 10%天然椰子油 (CNO)、米糠油 (RBO)、芝麻油 (SESO) 脂肪的饲粮、混合 (CNO+RBO 混合 (B)、CNO+SESO(B)) 或酯交换油 (CNO+RBO 酯交换 (I)、CNO+SESO(I)) 喂养 60 天。与饲粮中仅含 CNO 的大鼠相比，饲粮中添加 CNO+RBO(B)或 CNO+SESO(B)的大鼠 ADP 诱导的血小板聚集率分别降低了 34%和 30%。用 CNO 与 RBO 或 SESO 酯交换的混合油喂养的大鼠，胶原诱导的血小板聚集也相似减少。用 CNO+RBO(I)和 CNO+SESO(I)喂养大鼠，与饲粮中仅含 CNO 的大鼠相比，ADP 诱导的血小板聚集率也分别降低了 37%和 34%。与饲粮中仅含 CNO 的大鼠相比，饲粮中添加和酯交换脂肪的大鼠血清中前列环素/血栓素比值增加。这些结果表明，与单独用 CNO 喂养大鼠相比，CNO 与 RBO 或 SESO 混合或酯交换后具有抗血栓形成作用。
