Department of Mechanical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.
Curr Opin Chem Biol. 2010 Oct;14(5):616-22. doi: 10.1016/j.cbpa.2010.06.186. Epub 2010 Jul 30.
Nanotechnology has held great promise for revolutionizing biology. The biological behavior of nanomaterials depends primarily on how they interface to biomolecules and their surroundings. Unfortunately, interface issues like non-specific adsorption are still the biggest obstacles to the success of nanobiotechnology and nanomedicine, and have held back widespread practical use of nanotechnology in biology. Not only does the biological interface of nanoparticles (NPs) need to be understood and controlled, but also NPs must be treated as biological entities rather than inorganic ones. Furthermore, one can adopt an engineering perspective of the NP-biological interface, realizing that it has unique, exploitable properties.
纳米技术在生物学领域具有巨大的变革潜力。纳米材料的生物学行为主要取决于它们与生物分子及其周围环境的相互作用。不幸的是，界面问题（如非特异性吸附）仍然是纳米生物技术和纳米医学成功的最大障碍，也阻碍了纳米技术在生物学中的广泛实际应用。不仅需要理解和控制纳米颗粒（NPs）的生物学界面，而且还必须将 NPs 视为生物实体，而不是无机实体。此外，可以采用 NP-生物界面的工程学视角，认识到它具有独特的、可开发的特性。
