一种非侵入性传递方法、Cuproferrogel 氧化铁-铜-苯乙烯-马来酸酐-二甲基亚砜在雌性动物中的生物分布和生育控制潜力评估。

An approach to noninvasive delivery, biodistribution, and fertility control potential evaluation of the Cuproferrogel iron oxide-copper-styrene maleic anhydride-dimethyl sulphoxide in the female.

机构信息

School of Medical Science and Technology (SMST), Indian Institute of Technology, Kharagpur, West Bengal, India.

出版信息

Fertil Steril. 2010 Dec;94(7):2850-3. doi: 10.1016/j.fertnstert.2010.06.032. Epub 2010 Aug 1.

DOI:10.1016/j.fertnstert.2010.06.032

PMID:20674910

Abstract

Under guidance of an external pulsed magnetic field the Cuproferrogel iron oxide-copper-styrene maleic anhydride-dimethyl sulphoxide delivered into the rat/rabbit oviduct resulted in oocytes with granulated cytoplasm, zona enlargement, membrane disintegration, and finally loss of viability in 72 hours. Also, the percentage biodistribution of magnetic and electrically conductive particles observed under safe level advocates the use of Cuproferrogel as a potential female fertility control molecule.

摘要

在外部脉冲磁场的引导下，将进入大鼠/兔输卵管的铜铁凝胶氧化铁-铜-苯乙烯-马来酸酐-二甲基亚砜输送到卵母细胞中，导致卵母细胞的细胞质颗粒化、透明带膨胀、膜崩解，最终在 72 小时内失去活力。此外，在安全水平下观察到的磁性和导电性颗粒的生物分布百分比表明，铜铁凝胶可用作潜在的女性生育控制分子。