MRC Epidemiology Resource Centre, University of Southampton, UK.
Early Hum Dev. 2010 Sep;86(9):535-40. doi: 10.1016/j.earlhumdev.2010.07.002. Epub 2010 Aug 2.
We examined the differential associations of each parent's height and BMI with fetal growth, and examined the pattern of the associations through gestation. Data are from 557 term pregnancies in the Pune Maternal Nutrition Study. Size and conditional growth outcomes from 17 to 29 weeks to birth were derived from ultrasound and birth measures of head circumference, abdominal circumference, femur length and placental volume (at 17 weeks only). Parental height was positively associated with fetal head circumference and femur length. The associations with paternal height were detectible earlier in gestation (17-29 weeks) compared to the associations with maternal height. Fetuses of mothers with a higher BMI had a smaller mean head circumference at 17 weeks, but caught up to have larger head circumference at birth. Maternal but not paternal BMI, and paternal but not maternal height, were positively associated with placental volume. The opposing associations of placenta and fetal head growth with maternal BMI at 17 weeks could indicate prioritisation of early placental development, possibly as a strategy to facilitate growth in late gestation. This study has highlighted how the pattern of parental-fetal associations varies over gestation. Further follow-up will determine whether and how these variations in fetal/placental development relate to health in later life.
我们研究了父母身高和 BMI 与胎儿生长的差异关联，并通过孕期检查了关联模式。数据来自浦那母婴营养研究中的 557 例足月妊娠。从 17 周到出生的头围、腹围、股骨长度和胎盘体积（仅在 17 周时）的超声和出生测量中得出了大小和条件生长结果。父母身高与胎儿头围和股骨长度呈正相关。与母亲身高相比，父亲身高与胎儿生长的关联在孕期更早（17-29 周）即可检测到。母亲 BMI 较高的胎儿在 17 周时的平均头围较小，但在出生时头围较大。母亲 BMI 与胎盘体积呈正相关，但父亲 BMI 与胎盘体积呈正相关。母亲 BMI 与 17 周胎儿头围生长的相反关联可能表明早期胎盘发育的优先化，这可能是促进晚期妊娠生长的一种策略。本研究强调了父母-胎儿关联模式随孕期的变化。进一步的随访将确定这些胎儿/胎盘发育的变化是否以及如何与以后的生活健康相关。
