Effect of in utero and early-life conditions on adult health and disease.
作者信息
Gluckman Peter D, Hanson Mark A, Cooper Cyrus, Thornburg Kent L
机构信息
Liggins Institute, University of Auckland, and National Research Centre for Growth and Development, Auckland, New Zealand.
出版信息
N Engl J Med. 2008 Jul 3;359(1):61-73. doi: 10.1056/NEJMra0708473.
Abstract
摘要
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Effect of in utero and early-life conditions on adult health and disease.子宫内及生命早期状况对成人健康与疾病的影响。
N Engl J Med. 2008 Jul 3;359(1):61-73. doi: 10.1056/NEJMra0708473.
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In utero and early-life conditions and adult health and disease.子宫内及生命早期状况与成人健康和疾病。
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In utero and early-life conditions and adult health and disease.子宫内及生命早期状况与成人健康和疾病。
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Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19351-6. doi: 10.1073/pnas.0707258104. Epub 2007 Nov 27.
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Genomic imprinting, growth control and the allocation of nutritional resources: consequences for postnatal life.基因组印记、生长控制与营养资源分配：对出生后生活的影响
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Vitamin B12 and folate concentrations during pregnancy and insulin resistance in the offspring: the Pune Maternal Nutrition Study.孕期维生素B12和叶酸浓度与子代胰岛素抵抗：浦那孕产妇营养研究
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Metabolic plasticity during mammalian development is directionally dependent on early nutritional status.哺乳动物发育过程中的代谢可塑性在方向上依赖于早期营养状况。
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Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.对14000例七种常见疾病患者及3000例共享对照进行全基因组关联研究。
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Childhood obesity and metabolic imprinting: the ongoing effects of maternal hyperglycemia.儿童肥胖与代谢印记：母亲高血糖的持续影响
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A common variant of the PAX2 gene is associated with reduced newborn kidney size.PAX2基因的一种常见变体与新生儿肾脏尺寸减小有关。
J Am Soc Nephrol. 2007 Jun;18(6):1915-21. doi: 10.1681/ASN.2006101107. Epub 2007 May 18.
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Mismatched pre- and postnatal nutrition leads to cardiovascular dysfunction and altered renal function in adulthood.产前和产后营养不匹配会导致成年后心血管功能障碍和肾功能改变。
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