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Effect of in utero and early-life conditions on adult health and disease.

作者信息

Gluckman Peter D, Hanson Mark A, Cooper Cyrus, Thornburg Kent L

机构信息

Liggins Institute, University of Auckland, and National Research Centre for Growth and Development, Auckland, New Zealand.

出版信息

N Engl J Med. 2008 Jul 3;359(1):61-73. doi: 10.1056/NEJMra0708473.

DOI:10.1056/NEJMra0708473
PMID:18596274
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3923653/
Abstract
摘要

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DNA methylation, insulin resistance, and blood pressure in offspring determined by maternal periconceptional B vitamin and methionine status.孕期母亲B族维生素和蛋氨酸状态对后代DNA甲基化、胰岛素抵抗及血压的影响
Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19351-6. doi: 10.1073/pnas.0707258104. Epub 2007 Nov 27.
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Genomic imprinting, growth control and the allocation of nutritional resources: consequences for postnatal life.基因组印记、生长控制与营养资源分配：对出生后生活的影响
Curr Opin Endocrinol Diabetes Obes. 2007 Feb;14(1):3-12. doi: 10.1097/MED.0b013e328013daa2.
3
Vitamin B12 and folate concentrations during pregnancy and insulin resistance in the offspring: the Pune Maternal Nutrition Study.孕期维生素B12和叶酸浓度与子代胰岛素抵抗：浦那孕产妇营养研究
Diabetologia. 2008 Jan;51(1):29-38. doi: 10.1007/s00125-007-0793-y. Epub 2007 Sep 13.
4
The nature of the growth pattern and of the metabolic response to fasting in the rat are dependent upon the dietary protein and folic acid intakes of their pregnant dams and post-weaning fat consumption.大鼠生长模式的性质以及对禁食的代谢反应取决于其怀孕母鼠的膳食蛋白质和叶酸摄入量以及断奶后的脂肪消耗量。
Br J Nutr. 2008 Mar;99(3):540-9. doi: 10.1017/S0007114507815819. Epub 2007 Aug 29.
5
Metabolic plasticity during mammalian development is directionally dependent on early nutritional status.哺乳动物发育过程中的代谢可塑性在方向上依赖于早期营养状况。
Proc Natl Acad Sci U S A. 2007 Jul 31;104(31):12796-800. doi: 10.1073/pnas.0705667104. Epub 2007 Jul 23.
6
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.对14000例七种常见疾病患者及3000例共享对照进行全基因组关联研究。
Nature. 2007 Jun 7;447(7145):661-78. doi: 10.1038/nature05911.
7
Childhood obesity and metabolic imprinting: the ongoing effects of maternal hyperglycemia.儿童肥胖与代谢印记：母亲高血糖的持续影响
Diabetes Care. 2007 Sep;30(9):2287-92. doi: 10.2337/dc06-2361. Epub 2007 May 22.
8
A common variant of the PAX2 gene is associated with reduced newborn kidney size.PAX2基因的一种常见变体与新生儿肾脏尺寸减小有关。
J Am Soc Nephrol. 2007 Jun;18(6):1915-21. doi: 10.1681/ASN.2006101107. Epub 2007 May 18.
9
Glucose regulation in young adults with very low birth weight.极低出生体重的年轻成年人的血糖调节
N Engl J Med. 2007 May 17;356(20):2053-63. doi: 10.1056/NEJMoa067187.
10
Mismatched pre- and postnatal nutrition leads to cardiovascular dysfunction and altered renal function in adulthood.产前和产后营养不匹配会导致成年后心血管功能障碍和肾功能改变。
Proc Natl Acad Sci U S A. 2007 May 29;104(22):9529-33. doi: 10.1073/pnas.0610373104. Epub 2007 May 4.