Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands.
Med Eng Phys. 2010 Nov;32(9):957-67. doi: 10.1016/j.medengphy.2010.06.010. Epub 2010 Aug 1.
To estimate arterial stiffness, different methods based either on distensibility, pulse wave velocity or a pressure-velocity loop, have been proposed. These methods can be employed to determine the arterial mechanical properties either locally or globally, e.g. averaged over an entire arterial segment. The aim of this study was to investigate the feasibility of a new method that estimates distributed arterial mechanical properties non-invasively. This new method is based on a wave propagation model and several independent ultrasound and pressure measurements. Model parameters (including arterial mechanical properties) are obtained from a reverse method in which differences between modeling results and measurements are minimized using a fitting procedure based on local sensitivity indices. This study evaluates the differences between in vivo measured and simulated blood pressure and volume flow waveforms at the brachial, radial and ulnar arteries of 6 volunteers. The estimated arterial Young's modulus range from 1.0 to 6.0MPa with an average of (3.8±1.7)MPa at the brachial artery and from 1.2 to 7.8MPa with an average of (4.8±2.2)MPa at the radial artery. A good match between measured and simulated waveforms and the realistic stiffness parameters indicate a good in vivo suitability.
为了评估动脉僵硬度，已经提出了不同的方法，这些方法基于可扩展性、脉搏波速度或压力-速度环。这些方法可用于确定局部或整体的动脉力学特性，例如，在整个动脉段上平均。本研究的目的是研究一种新的非侵入性估计分布动脉力学特性的方法的可行性。这种新方法基于波传播模型和几个独立的超声和压力测量。通过反向方法获得模型参数（包括动脉力学特性），该方法使用基于局部灵敏度指数的拟合程序，使建模结果和测量值之间的差异最小化。本研究评估了 6 名志愿者肱动脉、桡动脉和尺动脉的体内测量和模拟血压和容积流量波形之间的差异。估计的动脉杨氏模量范围为 1.0 至 6.0MPa，肱动脉的平均值为（3.8±1.7）MPa，桡动脉的杨氏模量范围为 1.2 至 7.8MPa，平均值为（4.8±2.2）MPa。测量和模拟波形之间的良好匹配以及现实的弹性参数表明该方法具有良好的体内适用性。
