Physics Department, International Laser Center, M.V. Lomonosov Moscow State University, Russia.
J Biophotonics. 2010 Oct;3(10-11):660-9. doi: 10.1002/jbio.201000041.
Specialty fiber probes are used for in vivo depth-resolved mapping of neuron activity through the optical detection of fluorescent-protein reporters expressed inside the living brain of anesthetized transgenic mice. Supercontinuum radiation produced by highly nonlinear photonic-crystal fibers is employed to demonstrate a simultaneous multicolor interrogation of several biomarkers in a model aqueous solution system, thus suggesting the way toward a multiplex mapping of various types of neuron dynamics inside the living brain.
专业光纤探头用于通过对麻醉转基因小鼠活体大脑内表达的荧光蛋白报告基因的光学检测，对神经元活动进行体内深度分辨测绘。利用超连续谱辐射，通过高度非线性的光子晶体光纤来演示对模型水溶液体系中多个生物标记物的同时多色检测，从而为在活体大脑内对各种类型的神经元动力学进行多重测绘提供了一种可能的途径。
