Department of Radiology and Biomedical Imaging, University of California San Francisco, 94121, USA.
Alcohol. 2010 May;44(3):201-10. doi: 10.1016/j.alcohol.2010.03.003.
Relapse to hazardous levels of alcohol consumption after treatment for alcohol use disorders is common. Investigation of the neurobiological correlates of resumption of hazardous drinking is necessary to clarify the mechanisms contributing to relapse. Fifty-seven treatment-seeking alcohol-dependent participants (ALC) completed arterial spin labeling perfusion MRI of the frontal and parietal gray matter (GM) at 7+/-3 days of abstinence (baseline). ALC participants were restudied after 35+/-11 days of abstinence (assessment point 2: AP2). Twenty-eight nonsmoking, light-drinking control participants (nsLD) from the community were studied with perfusion MRI. ALC participants were followed over 12 months after baseline study and were classified as abstainers (no alcohol consumption; n=19) and resumers (any alcohol consumption; n=38) at follow-up. Cross-sectional and longitudinal perfusion was compared in abstainers, resumers, and nsLD. At baseline, resumers demonstrated significantly lower frontal and parietal GM perfusion than nsLD and abstainers. Abstainers and nsLD were not different on frontal or parietal GM perfusion. No significant longitudinal perfusion changes were observed in abstainers and resumers. At AP2, resumers showed significantly lower frontal GM perfusion than nsLD and abstainers, whereas no group differences were observed for parietal GM. Abstainers and nsLD were not different on frontal GM perfusion. The significantly decreased frontal GM perfusion in resumers compared with both abstainers and nsLD across the assessment interval suggests premorbid and/or acquired neurobiological abnormalities of the frontal GM in resumers.
治疗酒精使用障碍后，酒精消费恢复到危险水平是很常见的。研究恢复危险饮酒的神经生物学相关性对于阐明导致复发的机制是必要的。57 名寻求治疗的酒精依赖参与者（ALC）在戒断后 7+/-3 天（基线）完成了额叶和顶叶灰质（GM）的动脉自旋标记灌注 MRI。ALC 参与者在戒断后 35+/-11 天（评估点 2：AP2）再次接受研究。28 名来自社区的不吸烟、轻度饮酒的对照参与者（nsLD）接受了灌注 MRI 研究。ALC 参与者在基线研究后被随访 12 个月，并在随访时分为戒酒者（无饮酒；n=19）和复饮者（任何饮酒；n=38）。在戒酒者、复饮者和 nsLD 中比较了横断面和纵向灌注。在基线时，复饮者的额叶和顶叶 GM 灌注明显低于 nsLD 和戒酒者。戒酒者和 nsLD 在额叶或顶叶 GM 灌注上没有差异。在戒酒者和复饮者中没有观察到明显的纵向灌注变化。在 AP2，复饮者的额叶 GM 灌注明显低于 nsLD 和戒酒者，而顶叶 GM 则没有组间差异。戒酒者和 nsLD 在额叶 GM 灌注上没有差异。与戒酒者和 nsLD 相比，复饮者在整个评估间隔内额叶 GM 灌注明显降低，这表明复饮者存在前额叶 GM 的潜在和/或获得性神经生物学异常。
