Wrase Jana, Makris Nicos, Braus Dieter F, Mann Karl, Smolka Michael N, Kennedy David N, Caviness Verne S, Hodge Steven M, Tang Lena, Albaugh Matthew, Ziegler David A, Davis Orin C, Kissling Christian, Schumann Gunter, Breiter Hans C, Heinz Andreas
Department of Psychiatry, Charité-Universitätsmedizin Berlin, Charité Campus Mitte, Charitéplatz 1, 10117 Berlin, Germany.
Am J Psychiatry. 2008 Sep;165(9):1179-84. doi: 10.1176/appi.ajp.2008.07121877. Epub 2008 Jul 1.
Amygdala volume has been associated with drug craving in cocaine addicts, and amygdala volume reduction is observed in some alcohol-dependent subjects. This study sought an association in alcohol-dependent subjects between volumes of reward-related brain regions, alcohol craving, and the risk of relapse.
Besides alcohol craving, the authors assessed amygdala, hippocampus, and ventral striatum volumes in 51 alcohol-dependent subjects and 52 age- and education-matched healthy comparison subjects after detoxification. After imaging and clinical assessment, patients were followed for 6 months and alcohol intake was recorded.
Alcohol-dependent subjects showed reduced amygdala, hippocampus, and ventral striatum volumes and reported stronger craving in relation to healthy comparison subjects. However, only amygdala volume and craving differentiated between subsequent relapsers and abstainers. A significant decrease of amygdala volume in alcohol-dependent subjects was associated with increased alcohol craving before imaging and an increased alcohol intake during the 6-month follow-up period.
These findings suggest a relationship between amygdala volume reduction, alcohol craving, and prospective relapse into alcohol consumption.
杏仁核体积与可卡因成瘾者的药物渴望有关，并且在一些酒精依赖者中观察到杏仁核体积减小。本研究旨在探寻酒精依赖者中与奖赏相关的脑区体积、酒精渴望和复发风险之间的关联。
除了酒精渴望，作者在51名酒精依赖者和52名年龄及教育程度匹配的健康对照者戒毒后评估了杏仁核、海马体和腹侧纹状体的体积。在成像和临床评估后，对患者进行了6个月的随访并记录酒精摄入量。
与健康对照者相比，酒精依赖者的杏仁核、海马体和腹侧纹状体体积减小，且报告有更强烈的渴望。然而，只有杏仁核体积和渴望能区分后续的复发者和戒酒者。酒精依赖者杏仁核体积的显著减小与成像前酒精渴望增加以及6个月随访期内酒精摄入量增加有关。
这些发现表明杏仁核体积减小、酒精渴望和酒精消费的前瞻性复发之间存在关联。
Zotero 插件