Bjerring P, Andersen P H, Arendt-Nielsen L
Department of Dermatology, Marselisborg Hospital, Aarhus, Denmark.
Br J Anaesth. 1989 Dec;63(6):655-60. doi: 10.1093/bja/63.6.655.
We investigated vascular responses after cutaneous application of EMLA cream (a eutectic mixture of lignocaine and prilocaine) by skin reflectance spectroscopy and laser Doppler blood flowmetry. In healthy subjects, EMLA cream produced a biphasic vascular response with an initial vasoconstriction, maximal after 1.5 h of application. After prolonged application (greater than 3 h, vasodilatation occurred, presumably because of a smooth muscle relaxant effect of the analgesics. Vasoconstriction was also observed initially with two non-EMLA creams applied under occlusion, whereas the occlusive plastic film alone did not alter the vascular state. Thus late vasodilatation was unique to EMLA cream.
我们通过皮肤反射光谱法和激光多普勒血流仪研究了外用复方利多卡因乳膏（一种利多卡因和丙胺卡因的共熔混合物）后的血管反应。在健康受试者中，复方利多卡因乳膏产生了双相血管反应，最初是血管收缩，在用药1.5小时后达到最大程度。长时间用药（超过3小时）后，出现血管扩张，推测是由于镇痛药的平滑肌松弛作用。在封闭条件下使用两种非复方利多卡因乳膏时，最初也观察到血管收缩，而单独使用封闭性塑料薄膜并未改变血管状态。因此，后期血管扩张是复方利多卡因乳膏所特有的。
