Simonato L, L'Abbé K A, Andersen A, Belli S, Comba P, Engholm G, Ferro G, Hagmar L, Langård S, Lundberg I
International Agency for Research on Cancer, Lyon, France.
Scand J Work Environ Health. 1991 Jun;17(3):159-69. doi: 10.5271/sjweh.1715.
A large European multicentric cohort study has been coordinated by the International Agency for Research on Cancer with the objectives of investigating the dose-response relationship between liver cancer and exposure to vinyl chloride and assessing cancer risk for sites other than the liver. A nearly threefold increase in liver cancer was detected on the basis of 24 observed deaths and 8.4 expected (standardized mortality ratio 286, 95% confidence interval 186-425). The excess from liver cancer was clearly related to time since first exposure, duration of employment, and estimated ranked and quantitative exposures. Other cancer sites investigated on the basis of a priori hypotheses were either not in excess (lung) or apparently unrelated to the exposure variables (brain and lymphoma).
国际癌症研究机构协调开展了一项大型欧洲多中心队列研究，旨在调查肝癌与氯乙烯暴露之间的剂量反应关系，并评估肝脏以外部位的癌症风险。基于24例观察到的死亡病例和8.4例预期死亡病例（标准化死亡比286，95%置信区间186 - 425），检测到肝癌发病率几乎增加了两倍。肝癌的超额发病率与首次暴露后的时间、工作时长以及估计的暴露等级和定量暴露明显相关。基于先验假设调查的其他癌症部位要么没有超额发病（肺癌），要么与暴露变量明显无关（脑癌和淋巴瘤）。
