National Centre for Naturopathic Medicine, Southern Cross University, Lismore, NSW2480, Australia.
School of Public Health, University of Technology Sydney, Ultimo, NSW2007, Australia.
Br J Nutr. 2024 Jan 28;131(2):214-218. doi: 10.1017/S000711452300168X. Epub 2023 Jul 31.
Emerging evidence suggests that diet therapy (nutrients, foods and dietary patterns) could be effective as a potential adjunctive treatment option for major depressive disorder. Numerous mechanisms have been proposed, including the role inflammation, oxidative stress, brain-derived neurotrophic factor, the gastrointestinal tract microbiome and tryptophan/serotonin metabolism. Despite known differences in depression characteristics and treatment responses between males and females, there are limited sex-specific studies examining the role of diet in young men specifically. This is important as young men are often reluctant to seek mental health support, so finding treatment strategies which appeal to this demographic is crucial. This brief report provides an overview of the most recent advances in the use of diet for preventing and treating depression in young men, highlighting existing challenges and opportunities for future research. We recommend that clinicians discuss the role of diet with depressed young men, so that diet may be used alongside current treatment options.
新出现的证据表明，饮食疗法（营养素、食物和饮食模式）可能是一种有效的辅助治疗选择，可以用于治疗重度抑郁症。提出了许多机制，包括炎症、氧化应激、脑源性神经营养因子、胃肠道微生物组和色氨酸/血清素代谢的作用。尽管男性和女性的抑郁症特征和治疗反应存在已知差异，但专门针对年轻男性饮食作用的研究非常有限。这一点很重要，因为年轻男性通常不愿意寻求心理健康支持，因此找到吸引这一年龄段人群的治疗策略至关重要。本简要报告概述了最近在使用饮食预防和治疗年轻男性抑郁症方面的进展，强调了未来研究的现有挑战和机遇。我们建议临床医生与抑郁的年轻男性讨论饮食的作用，以便在当前治疗方案的基础上同时使用饮食疗法。
