前列腺素（PG）对豚鼠爪部缓激肽诱导的痛觉过敏和水肿的调节作用——前列腺素D2、前列腺素E2和前列环素I2的影响

Prostaglandin (PG) modulation of bradykinin-induced hyperalgesia and oedema in the guinea-pig paw--effects of PGD2, PGE2 and PGI2.

作者信息

Whelan C J, Head S A, Poll C T, Coleman R A

机构信息

Department of Peripheral Pharmacology, Glaxo Group Research Ltd., Ware, Herts., U.K.

出版信息

Agents Actions Suppl. 1991;32:107-11. doi: 10.1007/978-3-0348-7405-2_14.

DOI:10.1007/978-3-0348-7405-2_14

PMID:2069078

Abstract

The relative potencies of PGD2, PGE2 and PGI2 in potentiating bradykinin-induced hyperalgesia and oedema were determined in the paws of aspirin-treated guinea-pigs. PGE2 and to a lesser degree PGD2 but not PGI2, potentiated bradykinin-induced hyperalgesia, whereas PGD2, but not PGE2 or PGI2, potentiated oedema. These findings differ from those in other species, and possibly reflect interspecies differences in modulation of inflammatory reactions by prostanoids.

摘要

在经阿司匹林处理的豚鼠爪部测定了前列腺素D2（PGD2）、前列腺素E2（PGE2）和前列环素（PGI2）增强缓激肽诱导的痛觉过敏和水肿的相对效力。PGE2以及程度较轻的PGD2可增强缓激肽诱导的痛觉过敏，而PGI2则无此作用；PGD2可增强水肿，而PGE2和PGI2则无此作用。这些发现与其他物种不同，可能反映了前列腺素类物质对炎症反应调节的种间差异。