Department of Obstetrics & Gynecology, Faculty of Medicine, Fatih University, Ankara, Turkey.
Climacteric. 2011 Apr;14(2):262-7. doi: 10.3109/13697137.2010.500747. Epub 2010 Aug 7.
The aim of this study was to examine the effect of tibolone on hearing function in postmenopausal women.
This prospective study involved 60 postmenopausal women. Participants were randomly divided into two groups. The tibolone group was assigned to receive a tibolone tablet daily (n = 30). The other 30 cases who had not received any kind of hormone therapy were taken as the control group. The hearing levels of both ears in all women were measured by audiometry before initiation of tibolone therapy and 6 months after therapy.
The baseline hearing threshold levels of the two groups were similiar. After 6 months, audiometry results did not differ from baseline levels in the control group. In the tibolone group, there was some improvement in almost all hearing threshold levels after therapy. Statistically significant differences were only observed on the right side at pure tone audiometry and at the 500 and 6000 Hz levels.
Although tibolone has both gestagenic and androgenic properties together with estrogenic properties, no negative effect on hearing after 6 months of treatment was observed. On the contrary, there was significant improvement in audiometry results at low frequencies after 6 months' treatment. Although statistically not significant, there was some improvement at high frequencies.
本研究旨在探讨替勃龙对绝经后妇女听力功能的影响。
这是一项前瞻性研究，共纳入 60 例绝经后妇女。将参与者随机分为两组。替勃龙组每天服用替勃龙片（n=30）。另外 30 例未接受任何激素治疗的患者作为对照组。所有女性在开始替勃龙治疗前和治疗 6 个月后均通过听力计测量双耳听力水平。
两组的基线听力阈值水平相似。治疗 6 个月后，对照组的听力计结果与基线水平无差异。替勃龙组治疗后几乎所有听力阈值水平均有改善。仅在纯音听力测试和 500Hz 和 6000Hz 水平右侧观察到统计学显著差异。
尽管替勃龙具有孕激素、雄激素和雌激素特性，但治疗 6 个月后未观察到对听力的负面影响。相反，治疗 6 个月后低频听力计结果有显著改善。虽然统计学上不显著，但高频也有一定程度的改善。
