Closa R M, Tarres Roure A, Gómez Papi A, Casasin Edo T
Servicio de Pediatría, Hospital Joan XXIII, Tarragona.
An Esp Pediatr. 1989 Apr;30(4):269-71.
In order to defined the PO theophylline dose which produced effective theophylline concentrations between 4-10 micrograms/ml in prematures babies, we analized the theophylline pharmacokinetic of 6 adequate weight for gestational age female prematures, aged 31-34 gestational weeks, to which we administered PO 5 mg/kg of theophylline as the attack dose, following by a PO maintained dose of 2.5 mg/kg/12 h. In steady-state we did the pharmacokinetic studies after the administration of one dose. We found that only maintenance doses of 2.5 mg/kg/12 h produced therapeutic theophylline concentrations. Considering the pharmacokinetic data, we conclude that PO maintenance dose of 3 mg/kg/12 h of theophylline will be necessary to reach effective theophylline concentration.
为确定能使早产婴儿体内茶碱浓度维持在4 - 10微克/毫升的口服茶碱剂量，我们分析了6名孕龄31 - 34周、体重与孕龄相符的女性早产婴儿的茶碱药代动力学。我们给这些婴儿口服5毫克/千克的茶碱作为冲击剂量，随后给予2.5毫克/千克/12小时的口服维持剂量。在稳态时，我们在给予一剂药物后进行了药代动力学研究。我们发现只有2.5毫克/千克/12小时的维持剂量能产生治疗性的茶碱浓度。考虑到药代动力学数据，我们得出结论，要达到有效的茶碱浓度，口服茶碱维持剂量为3毫克/千克/12小时将是必要的。
