Gastroenterology Independent Operating Unit, Maggiore della Carità Hospital, Rome, Italy.
J Clin Gastroenterol. 2010 Sep;44 Suppl 1:S30-4. doi: 10.1097/MCG.0b013e3181ee31c3.
Evacuation disorders and hard stools are common in industrialized countries, affecting on average 12% to 17% of the adult healthy population at any age. Dietary supplementation with probiotic microorganisms may be useful in reducing the disorder.
We performed a double-blind, randomized, placebo-controlled study to evaluate the effectiveness of 2 different probiotic blends, either mixed Lactobacillus plantarum LP01 (LMG P-21021) and Bifidobacterium breve BR03 (DSM 16604) or Bifidobacterium animalis subspecies lactis BS01 (LMG P-21384), in the management of evacuation disorders and intestinal discomfort. In a period of 5 years (2003 to 2008), the study involved 300 healthy volunteers (151 males and 149 females; age 24 to 71 y) with evacuation disorders and hard stools. In particular, subjects were divided into 3 groups: 80 subjects in the group A received placebo, 110 subjects in the group B received mixed L. plantarum LP01 and B. breve BR03 (2.5 x 10 colony-forming units/d of each strain), and 110 subjects in the group C received B. animalis subsp. lactis BS01 (5 x 10 colony-forming units/d) for 30 days. At the beginning of the observational study, the healthy status of volunteers was evaluated by a complete, laboratory and ultrasound study of the abdomen. The physical examination was repeated after 15 and 30 days. In particular, the main troubles typically associated with evacuation disorders and hard stools as well as abdominal bloating were considered as parameters of interest. Exclusion criteria were items of gastrointestinal diseases and antibiotics intake.
Subjects treated with the mixed probiotic strains L. plantarum LP01 and B. breve BR03 or B. animalis subsp. lactis BS01 reported a significant improvement in the number of weekly bowel movements and in the main troubles associated with evacuations, particularly consistency of feces and ease of expulsion. Discomfort items such as abdominal bloating and anal itching, burning, or pain also registered a relevant improvement in the active groups receiving probiotics.
The intake of an effective amount of mixed L. plantarum LP01 and B. breve BR03 or B. animalis subsp. lactis BS01 for 30 days is able to significantly relieve the evacuation disorders and hard stools, thus providing a useful tool for the management of such condition, which is particularly widespread in industrialized countries at any age.
在工业化国家，排便障碍和硬便很常见，影响到任何年龄段的健康成年人的 12%至 17%。补充益生菌微生物可能有助于减少这种紊乱。
我们进行了一项双盲、随机、安慰剂对照研究，以评估两种不同益生菌混合物的有效性，即混合植物乳杆菌 LP01（LMG P-21021）和短双歧杆菌 BR03（DSM 16604）或动物双歧杆菌亚种乳双歧杆菌 BS01（LMG P-21384）在管理排便障碍和肠道不适方面的作用。在 5 年期间（2003 年至 2008 年），该研究涉及 300 名健康志愿者（151 名男性和 149 名女性；年龄 24 至 71 岁），他们有排便障碍和硬便。具体而言，受试者分为 3 组：80 名受试者服用安慰剂，110 名受试者服用混合 LP01 和 BR03（每种菌株 2.5×10 菌落形成单位/天），110 名受试者服用 BS01（5×10 菌落形成单位/天），持续 30 天。在观察研究开始时，通过对腹部的完整、实验室和超声研究评估志愿者的健康状况。15 天和 30 天后重复体检。特别是，将与排便障碍和硬便以及腹部胀气相关的主要困扰视为关注的参数。排除标准为胃肠道疾病和抗生素摄入项目。
服用混合益生菌菌株 LP01 和 BR03 或 BS01 的受试者每周排便次数显著增加，与排便相关的主要困扰，特别是粪便的一致性和排便的容易程度也得到显著改善。在接受益生菌治疗的活跃组中，腹胀等不适症状以及肛门瘙痒、灼热或疼痛也得到了显著改善。
摄入有效剂量的混合 LP01 和 BR03 或 BS01 30 天，能够显著缓解排便障碍和硬便，为管理这种在任何年龄段都广泛存在于工业化国家的疾病提供了有用的工具。
