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胃食管反流病：从病理生理学到治疗。

Gastroesophageal reflux disease: From pathophysiology to treatment.

机构信息

Department of Surgery, University of Chicago Pritzker School of Medicine, Chicago, IL 60637, United States.

出版信息

World J Gastroenterol. 2010 Aug 14;16(30):3745-9. doi: 10.3748/wjg.v16.i30.3745.

DOI:10.3748/wjg.v16.i30.3745
PMID:20698035
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2921084/
Abstract

This review focuses on the pathophysiology of gastroesophageal reflux disease (GERD) and its implications for treatment. The role of the natural anti-reflux mechanism (lower esophageal sphincter, esophageal peristalsis, diaphragm, and trans-diaphragmatic pressure gradient), mucosal damage, type of refluxate, presence and size of hiatal hernia, Helicobacter pylori infection, and Barrett's esophagus are reviewed. The conclusions drawn from this review are: (1) the pathophysiology of GERD is multifactorial; (2) because of the pathophysiology of the disease, surgical therapy for GERD is the most appropriate treatment; and (3) the genesis of esophageal adenocarcinoma is associated with GERD.

摘要

这篇综述主要关注胃食管反流病（GERD）的病理生理学及其对治疗的影响。文中回顾了天然抗反流机制（食管下括约肌、食管蠕动、膈肌和膈下压力梯度）、黏膜损伤、反流物类型、食管裂孔疝的存在和大小、幽门螺杆菌感染和巴雷特食管的作用。从这篇综述中得出的结论是：（1）GERD 的病理生理学是多因素的；（2）由于疾病的病理生理学，GERD 的手术治疗是最合适的治疗方法；（3）食管腺癌的发生与 GERD 有关。

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本文引用的文献

[1]
Proton pump inhibitors and histamine-2 receptor antagonists are associated with hip fractures among at-risk patients.

Gastroenterology. 2010-3-27

[2]
Medical versus surgical management for gastro-oesophageal reflux disease (GORD) in adults.

Cochrane Database Syst Rev. 2010-3-17

[3]
Proton pump inhibitors in the management of GERD.

J Gastrointest Surg. 2009-9-23

[4]
The molecular pathogenesis of Barrett's esophagus: common signaling pathways in embryogenesis metaplasia and neoplasia.

J Gastrointest Surg. 2009-9-16

[5]
Sonographic assessments of gastrointestinal and biliary functions.

Best Pract Res Clin Gastroenterol. 2009

[6]
Helicobacter pylori and gastroesophageal reflux disease: a review of this intriguing relationship.

Dis Esophagus. 2009

[7]
Gastroesophageal reflux disease and morbid obesity: is there a relation?

World J Surg. 2009-10

[8]
Comparison of reflux frequency during prolonged multichannel intraluminal impedance and pH monitoring on and off acid suppression therapy.

J Clin Gastroenterol. 2009-10

[9]
The spectrum of motor function abnormalities in gastroesophageal reflux disease and Barrett's esophagus.

Digestion. 2009

[10]
Environmental causes of esophageal cancer.

Gastroenterol Clin North Am. 2009-3

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