中国西安抗 HCV 反应性志愿献血者分布特征及基因型转变。

Anti-HCV reactive volunteer blood donors distribution character and genotypes switch in Xi'an, China.

机构信息

Department of Clinic Molecular Research Center& Clinic Diagnostic Laboratory, Xijing Hospital, Fourth Military Medical University, 17th Changlexi Road, Xi'an 710032, China.

出版信息

Virol J. 2010 Aug 10;7:186. doi: 10.1186/1743-422X-7-186.

DOI:10.1186/1743-422X-7-186

PMID:20698949

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2924864/

Abstract

HCV is prevailed in the world as well as in China. Blood transfusion is one of the most common transmission pathways of this pathogen. Although data of HCV infection character were reported during the past years, anti-HCV reactive profile of China donors was not fully clear yet. Furthermore, infection progress was found related to the HCV genotype. Different genotype led to different efficacy when interferon was introduced into HCV therapy. Here we provided character data of HCV infection in China blood donors from the year of 2000 to 2009. The infection rate in local donors was lower than general population and descended from 0.80% to 0.40% or so in recent years. About 83% HCV strains were categorized into genotypes 1b and 2a. But 1b subtype cases climbed and 2a subtype cases decreased. The current study threw more light on HCV infection of blood donors in China, at least in the Northern region.

摘要

HCV 在世界范围内广泛流行，在中国也不例外。输血是该病原体最常见的传播途径之一。尽管过去几年已经报道了 HCV 感染特征的数据，但中国献血者的抗-HCV 反应谱尚不完全清楚。此外，感染进展与 HCV 基因型有关。不同的基因型导致干扰素引入 HCV 治疗时的疗效不同。在这里，我们提供了 2000 年至 2009 年中国献血者 HCV 感染的特征数据。本地献血者的感染率低于一般人群，近年来已从 0.80%降至 0.40%左右。约 83%的 HCV 株分为 1b 和 2a 基因型。但 1b 亚型病例增加，2a 亚型病例减少。本研究至少在北方地区更深入地了解了中国献血者的 HCV 感染情况。