中国成都无偿献血者中丙型肝炎病毒基因型的分布

Distribution of hepatitis C virus genotypes in volunteer blood donors from Chengdu, China.

作者信息

Gong Tianxiang, Zhao Xin, Luo Yijia, Hong Ying, Li Shuping, Fu Xuemei

机构信息

Blood Research Laboratory, Chengdu Blood Center, Chengdu, 610041, Sichuan, China.

Blood Screening Laboratory, Chengdu Blood Center, Chengdu, 610041, Sichuan, China.

出版信息

Arch Virol. 2016 Jul;161(7):1873-82. doi: 10.1007/s00705-016-2865-0. Epub 2016 Apr 21.

DOI:10.1007/s00705-016-2865-0

PMID:27101072

Abstract

Hepatitis C virus (HCV) is a significant pathogen of global concern. The virus is usually spread through blood contact, such as transfusion, hemodialysis and injection of illegal drugs. HCV genotypes have a geographic distribution in different areas. In this paper, we focus on the distribution of HCV genotypes from volunteer blood donors in Chengdu. The prevalence of genotypes was analyzed using phylogenetic analysis. Phylogenetic trees were constructed based on the HCV core and NS5B regions from 313 sequences. HCV sequences were classified into six subtypes, and HCV genotypes were determined with the following results: 1b in 283, 2a in 14, 3b in seven, 3a in three, 6a in five and 6u in one. Subtype 1b was the most common and accounted for approximately 90.41 % (283/313), and a virus of subtype 6u was isolated for the first time from the Chengdu area. Genotypes 4 and 5 were not detected.

摘要

丙型肝炎病毒（HCV）是一种引起全球关注的重要病原体。该病毒通常通过血液接触传播，如输血、血液透析和注射非法药物。HCV基因型在不同地区有地理分布。在本文中，我们重点关注成都无偿献血者中HCV基因型的分布情况。使用系统发育分析对基因型的流行情况进行了分析。基于313个序列的HCV核心区和NS5B区构建了系统发育树。HCV序列被分为六个亚型，确定的HCV基因型结果如下：1b型283例，2a型14例，3b型7例，3a型3例，6a型5例，6u型1例。1b型是最常见的，约占90.41%（283/313），并且首次从成都地区分离出6u型病毒。未检测到4型和5型基因型。