Narukawa Masataka, Koizumi Kanako, Iwasaki Yusaku, Kubota Kikue, Watanabe Tatsuo
Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, Yada, Suruga-ku, Shizuoka, Japan.
Biosci Biotechnol Biochem. 2010;74(8):1694-6. doi: 10.1271/bbb.100133. Epub 2010 Aug 7.
We investigated the activation of transient receptor potential cation channel (TRP) subfamily V, member 1 (TRPV1) and TRP subfamily A, member 1 (TRPA1) by 1'-acetoxychavicol acetate (ACA), the main pungent component in galangal. ACA did not activate TRPV1-expressing human embryonic kidney (HEK) cells, but strongly activated TRPA1-expressing HEK cells. ACA was more potent than allyl isothiocyanate, the typical TRPA1 agonist.
我们研究了高良姜中的主要辛辣成分乙酸1'-乙酰氧基胡椒酚酯（ACA）对瞬时受体电位阳离子通道（TRP）V亚家族成员1（TRPV1）和TRP A亚家族成员1（TRPA1）的激活作用。ACA未激活表达TRPV1的人胚肾（HEK）细胞，但强烈激活了表达TRPA1的HEK细胞。ACA比典型的TRPA1激动剂异硫氰酸烯丙酯更有效。
