Brown Joshua B, Stassen Nicole A, Cheng Julius D, Sangosanya Ayodele T, Bankey Paul E, Gestring Mark L
Department of Surgery, University of Rochester School of Medicine, Rochester, New York 14642-8410, USA.
J Trauma. 2010 Aug;69(2):263-9. doi: 10.1097/TA.0b013e3181e5d72e.
The mortality of traumatic brain injury (TBI) continues to decline, emphasizing functional outcomes. Trauma center designation has been linked to survival after TBI, but the impact on functional outcomes is unclear. The objective was to determine whether trauma center designation influenced functional outcomes after moderate and severe TBI.
Trauma subjects presenting to an American College of Surgeons (ACS) Level I or II trauma center with a Glasgow Coma Score (GCS) <or=12 who survived to discharge were identified using the National Trauma Databank (2002-2006). Outcomes were functional independence (FI) defined as a modified functional independence measure (FIM) of 12, and independent expression (IE) defined as a FIM component of 4. These were compared between Level I and Level II centers in subjects with both moderate (GCS 9-12) and severe (GCS <or=8) TBI using stepwise logistic regression to adjust for demographics, injuries, and comorbidities.
Analysis identified 25,170 subjects (72% severe TBI). After adjusting for covariates, ACS Level I designation was associated with FI (odds ratio: 1.16; confidence interval: 1.07-1.24, p < 0.01) and IE (1.10; 1.03-1.17, p < 0.01) after severe TBI. Trauma center designation was not associated with FI or IE after moderate TBI.
ACS trauma center designation is significantly associated with FI and IE after severe, but not moderate TBI. Prospective study is warranted to verify and explore factors contributing to this discrepancy.
创伤性脑损伤(TBI)的死亡率持续下降,功能结局愈发受到重视。创伤中心的指定与TBI后的生存率相关,但对功能结局的影响尚不清楚。本研究目的是确定创伤中心的指定是否会影响中度和重度TBI后的功能结局。
利用国家创伤数据库(2002 - 2006年),确定那些就诊于美国外科医师学会(ACS)一级或二级创伤中心、格拉斯哥昏迷评分(GCS)≤12且存活至出院的创伤患者。结局指标包括功能独立性(FI),定义为改良功能独立性测量(FIM)评分为12;以及独立表达(IE),定义为FIM的一个分量评分为4。在中度(GCS 9 - 12)和重度(GCS≤8)TBI患者中,使用逐步逻辑回归分析对一级和二级中心的患者进行比较,以调整人口统计学、损伤情况和合并症等因素。
分析共纳入25170例患者(72%为重度TBI)。在调整协变量后,ACS一级创伤中心与重度TBI后的FI(比值比:1.16;置信区间:1.07 - 1.24,p < 0.01)和IE(1.10;1.03 - 1.17,p < 0.01)相关。创伤中心的指定与中度TBI后的FI或IE无关。
ACS创伤中心的指定与重度TBI后的FI和IE显著相关,但与中度TBI无关。有必要进行前瞻性研究以验证并探究导致这种差异的因素。