Kitamura H
Department of Oral Histology, Kanagawa Dental College, Yokosuka, Japan.
Cleft Palate Craniofac J. 1991 Apr;28(2):195-210; discussion 210-1. doi: 10.1597/1545-1569_1991_028_0195_efcpaa_2.3.co_2.
Some clefts of the lip and palate appear to result from the rupture after fusion has occurred. This possibility is suggested by (1) epithelial remnants found in the palatal shelves, (2) regenerating epithelium found in the palatal clefts of human fetuses older than 13 weeks, (3) immature epithelium visible on the margin of the cleft, (4) nasopalatine ducts cut off by clefts, (5) perforation type cleft found in the hard palate, (6) a Simonart band visible in six cleft mouse fetuses, (7) duplicated upper lateral incisors enclosing a lip-jaw cleft, and (8) rodent cavities in the lip or palate related to cleft formation.
一些唇腭裂似乎是在融合发生后破裂所致。以下几点表明了这种可能性:(1)在腭突中发现的上皮残余物;(2)在13周以上人类胎儿的腭裂中发现的再生上皮;(3)在腭裂边缘可见的未成熟上皮;(4)被腭裂切断的鼻腭管;(5)硬腭中发现的穿孔型腭裂;(6)在六只腭裂小鼠胎儿中可见的西蒙纳尔带;(7)围绕唇颌裂的重复上侧切牙;(8)与腭裂形成相关的唇或腭中的啮齿类空洞。