Kiho T, Sakushima M, Wang S R, Nagai K, Ukai S
Gifu Pharmaceutical University, Mitahora-higashi 5-chome, Japan.
Chem Pharm Bull (Tokyo). 1991 Mar;39(3):798-800. doi: 10.1248/cpb.39.798.
Two water-insoluble glucans, U-3-N ([alpha]D +1.0 degree, 0.5 M sodium hydroxide) and U-3-AP1 ([alpha]D +2.5 degrees, 1 M sodium hydroxide) were isolated from hot-water extract of the fruiting bodies of Yũ ĕr (Chinese name) (Auricularia sp.). U-3-N and U-3-AP1 were investigated by a combination of chemical and spectroscopic methods. The results indicated that U-3-N (molecular weight, 6.1 x 10(5)) was similar to beta-(1----6)-branched (1----3)-beta-D-glucan (N-5P: molecular weight, 5.6 x 10(5)) isolated from the alkaline extract of the fruiting bodies, and U-3-AP1 (molecular weight, 6.3 x 10(4)) was beta-(1----6)-branched (1----3)-beta-D-glucan containing beta-(1----6)-linked D-glucopyranosyl residues. U-3-N showed potent anti-tumor activity against the solid form of sarcoma 180, although U-3-AP1 had little effect on the tumor.
从木耳（学名：Auricularia sp.）子实体的热水提取物中分离出两种水不溶性葡聚糖，U-3-N（[α]D +1.0度，0.5 M氢氧化钠）和U-3-AP1（[α]D +2.5度，1 M氢氧化钠）。采用化学和光谱方法相结合的方式对U-3-N和U-3-AP1进行了研究。结果表明，U-3-N（分子量为6.1×10⁵）与从子实体碱性提取物中分离出的β-(1→6)分支的(1→3)-β-D-葡聚糖（N-5P：分子量为5.6×10⁵）相似，而U-3-AP1（分子量为6.3×10⁴）是含有β-(1→6)连接的D-吡喃葡萄糖残基的β-(1→6)分支的(1→3)-β-D-葡聚糖。U-3-N对实体瘤肉瘤180显示出强大的抗肿瘤活性，而U-3-AP1对肿瘤几乎没有影响。
