Department of Biological Sciences, Columbia University, New York, NY 10027, USA.
Dev Cell. 2010 Aug 17;19(2):194-206. doi: 10.1016/j.devcel.2010.07.018.
Matrix and tissue rigidity guides many cellular processes, including the differentiation of stem cells and the migration of cells in health and disease. Cells actively and transiently test rigidity using mechanisms limited by inherent physical parameters that include the strength of extracellular attachments, the pulling capacity on these attachments, and the sensitivity of the mechanotransduction system. Here, we focus on rigidity sensing mediated through the integrin family of extracellular matrix receptors and linked proteins and discuss the evidence supporting these proteins as mechanosensors.
基质和组织硬度指导着许多细胞过程，包括干细胞的分化和健康与疾病状态下细胞的迁移。细胞通过受固有物理参数限制的机制，主动且短暂地检测硬度，这些参数包括细胞外附着的强度、对这些附着的拉力，以及机械转导系统的敏感性。在这里，我们重点关注通过整合素家族的细胞外基质受体和相关蛋白介导的硬度感知，并讨论支持这些蛋白作为机械感受器的证据。
