Disease Biophysics Group, Wyss Institute for Biologically Inspired Engineering, Harvard University, Cambridge, MA, USA.
Pflugers Arch. 2011 Jul;462(1):89-104. doi: 10.1007/s00424-011-0951-4. Epub 2011 Apr 19.
Mechanotransduction refers to the conversion of mechanical forces into biochemical or electrical signals that initiate structural and functional remodeling in cells and tissues. The heart is a kinetic organ whose form changes considerably during development and disease, requiring cardiac myocytes to be mechanically durable and capable of fusing a variety of environmental signals on different time scales. During physiological growth, myocytes adaptively remodel to mechanical loads. Pathological stimuli can induce maladaptive remodeling. In both of these conditions, the cytoskeleton plays a pivotal role in both sensing mechanical stress and mediating structural remodeling and functional responses within the myocyte.
机械转导是指将机械力转化为生化或电信号，从而引发细胞和组织的结构和功能重塑。心脏是一个动力器官，其形态在发育和疾病过程中会发生很大变化，这就要求心肌细胞具有机械耐久性，并能够在不同的时间尺度上融合各种环境信号。在生理性生长过程中，心肌细胞会适应性地重塑以适应机械负荷。病理刺激会导致适应性重塑不良。在这两种情况下，细胞骨架在感知机械应激以及介导心肌细胞内的结构重塑和功能反应方面都起着关键作用。
