US Geological Survey, Alaska Science Center, 4210 University Drive, Anchorage, AK 99508, USA.
Virology. 2010 Oct 25;406(2):352-9. doi: 10.1016/j.virol.2010.07.031. Epub 2010 Aug 14.
Twenty avian influenza viruses were isolated from seven wild migratory bird species sampled at St. Lawrence Island, Alaska. We tested predictions based on previous phylogenetic analyses of avian influenza viruses that support spatially dependent trans-hemispheric gene flow and frequent interspecies transmission at a location situated at the Asian-North American interface. Through the application of phylogenetic and genotypic approaches, our data support functional dilution by distance of trans-hemispheric reassortants and interspecific virus transmission. Our study confirms infection of divergent avian taxa with nearly identical avian influenza strains in the wild. Findings also suggest that H16N3 viruses may contain gene segments with unique phylogenetic positions and that further investigation of how host specificity may impact transmission of H13 and H16 viruses is warranted.
从阿拉斯加圣劳伦斯岛采集的七个野生候鸟物种中分离出了 20 种禽流感病毒。我们测试了基于先前的禽流感病毒系统发育分析的预测，这些预测支持在位于亚洲-北美界面的位置上存在空间依赖的跨半球基因流和频繁的种间传播。通过应用系统发育和基因型方法，我们的数据支持跨半球重配体和种间病毒传播的功能距离稀释。我们的研究证实了在野外，不同的鸟类类群感染了几乎相同的禽流感毒株。研究结果还表明，H16N3 病毒可能包含具有独特系统发育位置的基因片段，进一步研究宿主特异性如何影响 H13 和 H16 病毒的传播是有必要的。
