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H5进化枝2.3.4.4爆发之前阿拉斯加野生鸟类中甲型流感病毒的重配

Reassortment of Influenza A Viruses in Wild Birds in Alaska before H5 Clade 2.3.4.4 Outbreaks.

作者信息

Hill Nichola J, Hussein Islam T M, Davis Kimberly R, Ma Eric J, Spivey Timothy J, Ramey Andrew M, Puryear Wendy Blay, Das Suman R, Halpin Rebecca A, Lin Xudong, Fedorova Nadia B, Suarez David L, Boyce Walter M, Runstadler Jonathan A

出版信息

Emerg Infect Dis. 2017 Apr;23(4):654-657. doi: 10.3201/eid2304.161668.

DOI:10.3201/eid2304.161668
PMID:28322698
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5367406/
Abstract

Sampling of mallards in Alaska during September 2014-April 2015 identified low pathogenic avian influenza A virus (subtypes H5N2 and H1N1) that shared ancestry with highly pathogenic reassortant H5N2 and H5N1 viruses. Molecular dating indicated reassortment soon after interhemispheric movement of H5N8 clade 2.3.4.4, suggesting genetic exchange in Alaska or surrounds before outbreaks.

摘要

2014年9月至2015年4月期间在阿拉斯加对绿头鸭进行的采样发现了低致病性甲型禽流感病毒（H5N2和H1N1亚型），这些病毒与高致病性重配H5N2和H5N1病毒具有共同的祖先。分子年代测定表明，在H5N8进化分支2.3.4.4进行半球间移动后不久就发生了重配，这表明在疫情爆发前阿拉斯加或周边地区就发生了基因交换。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26d4/5367406/b6c1cbfcbf99/16-1668-F2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26d4/5367406/3a1b018f8841/16-1668-F1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26d4/5367406/b6c1cbfcbf99/16-1668-F2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26d4/5367406/3a1b018f8841/16-1668-F1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26d4/5367406/b6c1cbfcbf99/16-1668-F2.jpg

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