Laboratory for Ecophysiology, Biochemistry and Toxicology, Department of Biology, University of Antwerp, Groenenborgerlaan 171, 2020 Antwerp, Belgium.
Chemosphere. 2010 Sep;81(4):478-87. doi: 10.1016/j.chemosphere.2010.07.043. Epub 2010 Aug 14.
The increasing time spent indoors combined with the abundant usage of diverse indoor chemicals led to concerns involving the impact of these compounds on human health. The current study focused on two groups of important indoor contaminants i.e. Brominated flame retardants (BFRs) and Perfluorinated compounds (PFCs). Concentrations of both compound classes have been measured in Flemish indoor dust samples from homes and offices. ΣPolybrominated diphenyl ethers (PBDEs) (BDE 47, 99, 100, 154, 153, 197, 196 and 203) and BDE 209 in homes ranged between 4-1214 ng g(-1)dw (median 35) and <5-5295 ng g(-1)dw (median 313), respectively. Hexabromocyclododecane (ΣHBCD) levels ranged from 5 to 4,2692 ng g(-1)dw (median 130), with α-HBCD being the major isomer (mean 59%). In addition, tetrabromobisphenol A (TBBPA) ranged between <3 and 419 ng g(-1)dw (median 12). For all BFRs, median levels in office dust were up to an order of magnitude higher than in home dust. ΣPFCs (sum of perfluorobutane sulfonate (PFBS), perfluorohexane sulfonate (PFHxS), perfluorooctane sulfonic acid (PFOS), perfluorobutanoic acid (PFBA), perfluorohexanoic acid (PFHxA), perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA) and perfluorodecanoic acid (PFDA)) concentrations in homes ranged from 0.2 to 336 ng g(-1) (median 3.0 ng g(-1)). Levels in office dust were higher (p<0.01) than in house dust with ΣPFCs ranging between 2.2 and 647 ng g(-1) (median 10 ng g(-1)) and median (PFOA) and perfluorooctane sulfonate values of 2.9 and 2.2 ng g(-1), respectively. The congener pattern was dominated by PFOA, followed by PFOS. Calculated human exposure was below the reference dose values set by the US-EPA for BDE 209, HBCD and below the provisional tolerable daily intakes proposed by European Food Safety Authority for PFOS and PFOA.
室内活动时间的增加与各种室内化学物质的大量使用，导致人们开始关注这些化合物对人类健康的影响。本研究主要关注两类重要的室内污染物，即溴化阻燃剂（BFRs）和全氟化合物（PFCs）。在弗拉芒家庭和办公室的室内灰尘样本中测量了这两类化合物的浓度。家庭灰尘中的多溴联苯醚（PBDEs）（BDE-47、99、100、154、153、197、196 和 203）和 BDE-209 的浓度范围为 4-1214ng/g（中位数 35）和 <5-5295ng/g（中位数 313）。六溴环十二烷（ΣHBCD）的浓度范围为 5-4269.2ng/g（中位数 130），其中 α-HBCD 为主要异构体（平均 59%）。此外，四溴双酚 A（TBBPA）的浓度范围为 <3-419ng/g（中位数 12）。对于所有 BFRs，办公室灰尘中的浓度中位数比家庭灰尘中的浓度中位数高一个数量级。ΣPFCs（全氟丁烷磺酸（PFBS）、全氟己烷磺酸（PFHxS）、全氟辛烷磺酸（PFOS）、全氟丁酸（PFBA）、全氟己酸（PFHxA）、全氟辛酸（PFOA）、全氟壬酸（PFNA）和全氟癸酸（PFDA））浓度范围为 0.2-336ng/g（中位数 3ng/g）。办公室灰尘中的浓度更高（p<0.01），范围为 2.2-647ng/g（中位数 10ng/g），且 PFCs 的Σ值和全氟辛烷磺酸值分别为 2.9 和 2.2ng/g。同系物模式以 PFOA 为主，其次是 PFOS。计算出的人类暴露量低于美国环保署为 BDE-209、HBCD 设定的参考剂量值，也低于欧洲食品安全局为 PFOS 和 PFOA 提出的暂定每日耐受摄入量。
