Froehlich F, Fried M, Schnegg J F, Gonvers J J
Department of Gastroenterology, University Hospital, Lausanne, Switzerland.
Gastrointest Endosc. 1991 May-Jun;37(3):325-8. doi: 10.1016/s0016-5107(91)70724-4.
The salty unpleasant taste of the standard polyethylene glycol electrolyte lavage solution constitutes a major drawback, which limits patient compliance. Recently, a new low-sodium cleansing solution was described and introduced as a major advance, allegedly providing a distinctly better taste and improving compliance. We compared the taste of both solutions, seeking a possible preference applying a double-blind randomized design. Twenty-eight healthy volunteers tasted one of the two solutions without a direct comparison. Both solutions were found to have a similar palatability and an equal salty taste. A different group of 50 volunteers compared the two solutions. Twenty-one preferred the standard solution, 25 preferred the new solution (not significant), and 4 subjects had no preference. Among the subjects basing their preference on the saltiness of the solutions, 18 estimated the standard solution to taste more salty than the new low sodium solution, while 18 volunteers found the new solution to taste more salty than the standard solution. This study does not confirm a taste preference for the new low-salt polyethylene glycol electrolyte lavage solution as compared with the standard solution for colonic cleansing. The difference in the salt concentrations of the two solutions could not regularly be distinguished by a group of healthy volunteers.
标准聚乙二醇电解质灌洗液的咸味令人不适，这是一个主要缺点，限制了患者的依从性。最近，一种新的低钠清洁溶液被描述并作为一项重大进展引入，据称其口感明显更好，能提高依从性。我们采用双盲随机设计比较了两种溶液的味道，以探寻可能存在的偏好。28名健康志愿者分别品尝了两种溶液中的一种，没有进行直接比较。结果发现两种溶液的适口性相似，咸味相当。另一组50名志愿者对两种溶液进行了比较。21人更喜欢标准溶液，25人更喜欢新溶液（无显著差异），4人没有偏好。在根据溶液咸味做出偏好选择的受试者中，18人认为标准溶液比新的低钠溶液更咸，而18名志愿者则觉得新溶液比标准溶液更咸。这项研究并未证实与用于结肠清洁的标准溶液相比，新的低盐聚乙二醇电解质灌洗液在味道上更受青睐。一组健康志愿者无法经常区分两种溶液盐浓度的差异。
