MUC1 受体亚基在基因调控中的致癌功能。
Oncogenic function of the MUC1 receptor subunit in gene regulation.
机构信息
Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.
出版信息
Oncogene. 2010 Oct 21;29(42):5663-6. doi: 10.1038/onc.2010.334. Epub 2010 Aug 16.
Abstract
The mucin 1 (MUC1) oncoprotein is overexpressed by diverse human cancers; however, it has remained largely unclear how MUC1 contributes to tumorigenesis. In this issue of Oncogene and in concert with published work, Behrens et al. report that the MUC1 receptor subunit activates genes involved in invasion, angiogenesis and metastasis.
摘要
黏蛋白 1（MUC1）癌蛋白在多种人类癌症中过表达；然而，MUC1 如何促进肿瘤发生在很大程度上仍不清楚。在本期《Oncogene》杂志上，以及与已发表的工作一起，Behrens 等人报告说，MUC1 受体亚基激活了参与侵袭、血管生成和转移的基因。
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本文引用的文献
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