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益肾蠲痹丸对佐剂性关节炎的免疫调节作用。

Immunomodulatory activity of a Chinese herbal drug Yi Shen Juan Bi in adjuvant arthritis.

机构信息

Department of Physiology and Pharmacology, China Pharmaceutical University, Mailbox 207 Tongjiaxiang 24, Nanjing, Jiangsu, 210009, People's Republic of China.

出版信息

Indian J Pharmacol. 2010 Apr;42(2):65-9. doi: 10.4103/0253-7613.64489.

DOI:10.4103/0253-7613.64489
PMID:20711367
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2907016/
Abstract

OBJECTIVE

To investigate the immunomodulating mechanisms of a Chinese herbal medicine Yi Shen Juan Bi (YJB) in treatment of adjuvant arthritis (AA) in rats.

MATERIALS AND METHODS

Levels of serum tumor necrosis factor alpha (TNF-alpha) and interleukin-1beta (IL-1beta) were measured by the Enzyme-Linked Immunosorbent Assay (ELISA). Expression of TNF-alpha mRNA and IL-1beta mRNA in synovial cells was measured with the semi-quantitative technique of reverse transcription-polymerase chain reaction (RT-PCR), while caspase-3 was examined by western blot analysis.

RESULTS

The administration of YJB significantly decreased the production of serum TNF-alpha and IL-1beta. It also decreased significantly the TNF-alpha mRNA, IL-1beta mRNA, and caspase-3 expression in synoviocytes.

CONCLUSIONS

YJB produces the immunomodulatory effects by downregulating the over-activated cytokines, while it activates caspase-3, which is the key executioner of apoptosis in the immune system. This may be the one of the underlying mechanisms that explains how YJB treats the rheumatoid arthritis.

摘要

目的

研究中药益肾蠲痹丸（YJB）治疗佐剂性关节炎（AA）大鼠的免疫调节机制。

材料与方法

采用酶联免疫吸附试验（ELISA）测定血清肿瘤坏死因子-α（TNF-α）和白细胞介素-1β（IL-1β）水平。用逆转录-聚合酶链反应（RT-PCR）的半定量技术测定滑膜细胞中 TNF-α mRNA 和 IL-1β mRNA 的表达，并用 Western blot 分析检测 caspase-3。

结果

YJB 给药可显著降低血清 TNF-α和 IL-1β的产生。它还显著降低了滑膜细胞中 TNF-α mRNA、IL-1β mRNA 和 caspase-3 的表达。

结论

YJB 通过下调过度激活的细胞因子产生免疫调节作用，同时激活 caspase-3，caspase-3 是免疫系统中凋亡的关键执行者。这可能是解释 YJB 治疗类风湿关节炎的机制之一。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a6a/2907016/40f9e6c247ad/IJPharm-42-65-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a6a/2907016/c1e8ae9c1cc3/IJPharm-42-65-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a6a/2907016/e48010603678/IJPharm-42-65-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a6a/2907016/7e1f3c05690c/IJPharm-42-65-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a6a/2907016/5009bb88ffb1/IJPharm-42-65-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a6a/2907016/ac637d3f0102/IJPharm-42-65-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a6a/2907016/40f9e6c247ad/IJPharm-42-65-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a6a/2907016/c1e8ae9c1cc3/IJPharm-42-65-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a6a/2907016/e48010603678/IJPharm-42-65-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a6a/2907016/7e1f3c05690c/IJPharm-42-65-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a6a/2907016/5009bb88ffb1/IJPharm-42-65-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a6a/2907016/ac637d3f0102/IJPharm-42-65-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a6a/2907016/40f9e6c247ad/IJPharm-42-65-g006.jpg

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