用于无标记检测靶分子的模块化蓝色荧光RNA传感器。

Modular blue fluorescent RNA sensors for label-free detection of target molecules.

作者信息

Furutani Chika, Shinomiya Kazuki, Aoyama Yasuhiro, Yamada Katsuhiro, Sando Shinsuke

机构信息

Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku, 615-8510, Kyoto, Japan.

出版信息

Mol Biosyst. 2010 Sep;6(9):1569-71. doi: 10.1039/c001230k. Epub 2010 Mar 12.

DOI:10.1039/c001230k

PMID:20711536

Abstract

A blue fluorescent RNA was applied to modular blue fluorescent RNA sensors, wherein a "recognition" event of the target molecule by the aptamer domain is transmitted through a "communication" module, to a "signaling" fluorescent RNA domain, which "lights up".

摘要

一种蓝色荧光RNA被应用于模块化蓝色荧光RNA传感器，其中适体结构域对靶分子的“识别”事件通过“通信”模块传递到“信号”荧光RNA结构域，该结构域会“点亮”。