Institute of Endocrinology and Nutrition, Medicine School, Hospital Rio Hortega, Valladolid, Spain.
Eur Rev Med Pharmacol Sci. 2010 Jun;14(6):521-6.
Few studies have evaluated the relation between phase angle (PA) and metabolic syndrome. As long as we know, there are not studies of association between phase angle and adipocytokines. The aim of our study was to evaluate the association of adipocytokines levels and classical cardiovascular risk factors with tertiles of phase angle in obese women.
A cross-sectional study was designed to establish whether phase angle from 228 adult female patients with obesity are related with adipocitokynes and cardiovascular risk factors. These patients were studied in a Nutrition Clinic Unit after signed informed consent. All patients with a 2 weeks weight-stabilization period before recruitment were enrolled. Weight, blood pressure, basal glucose, C-reactive protein (CRP), insulin, total cholesterol, LDL-cholesterol, HDL-cholesterol, triglycerides blood and adypocitokines (leptin, adiponectin, resistin Interleukin-6 and TNF-alpha) levels were measured. The phase angle alpha was determined by bioimpedance with the equation [PA degrees =(Xc/R)x(180 degrees/pi)].
Two hundred and twenty-eight females gave informed consent and were enrolled in the study. The mean age was 38.2 +/- 14.7 years and the mean BMI 35.27 +/- 6.5. Patients were divided by tertiles of phase angle. Fat mass was higher in first tertile than third tertile (43.6 +/- 12.6 vs 40.9 +/- 15 kg: p<0.05). HOMA (2.4 +/- 1.6 vs 1.46 +/- 1.6: p<0.05), insulin (14.4 +/- 8.5 vs 11.3 +/- 9.4 mUI/L: p<0.05) and glucose (102.1 +/- 20 vs 90 +/- 19.5 mg/dl: p<0.05) levels were higher in first tertile than second and third tertiles. Leptin (167.3 +/- 98 vs 104.5 +/- 80 ng/ml: p<0.05) and IL-6 (3.84 +/- 5.7 vs 1.8 +/- 2.9 pg/ml: p<0.05) levels were higher in first phase angle tertile than third tertile phase angle.
Obese women with a low PA tertile have high fat mass with a secondary high level of glucose, HOMA, IL-6 and leptin. Perhaps, a low tertile of phase angle could be a new subrogate cardiovascular risk factor to categorize the obese patients.
很少有研究评估相位角（PA）与代谢综合征之间的关系。据我们所知，还没有研究相位角与脂肪细胞因子之间的关系。我们的研究目的是评估肥胖女性中相位角与脂肪细胞因子和经典心血管危险因素的三分位相关。
设计了一项横断面研究，以确定来自 228 名肥胖成年女性患者的相位角是否与脂肪细胞因子和心血管危险因素有关。在签署知情同意书后，在营养诊所对所有患者进行研究。所有患者在招募前都经过了 2 周的体重稳定期。测量体重、血压、基础血糖、C 反应蛋白（CRP）、胰岛素、总胆固醇、LDL-胆固醇、HDL-胆固醇、甘油三酯和脂肪细胞因子（瘦素、脂联素、抵抗素、白细胞介素-6 和 TNF-α）水平。通过生物阻抗法用公式 [PA 度=（Xc/R）x（180 度/π）] 确定相位角α。
228 名女性同意并参与了研究。平均年龄为 38.2±14.7 岁，平均 BMI 为 35.27±6.5。患者按相位角三分位分为三组。第一三分位的脂肪量高于第三三分位（43.6±12.6 比 40.9±15 公斤：p<0.05）。第一三分位的 HOMA（2.4±1.6 比 1.46±1.6：p<0.05）、胰岛素（14.4±8.5 比 11.3±9.4 mUI/L：p<0.05）和血糖（102.1±20 比 90±19.5 mg/dl：p<0.05）水平高于第二和第三三分位。第一相位角三分位的瘦素（167.3±98 比 104.5±80 ng/ml：p<0.05）和白细胞介素-6（3.84±5.7 比 1.8±2.9 pg/ml：p<0.05）水平高于第三相位角三分位。
相位角低三分位的肥胖女性脂肪量较高，其次是血糖、HOMA、白细胞介素-6 和瘦素水平较高。也许，相位角的低三分位可以作为一种新的替代心血管危险因素，对肥胖患者进行分类。
