Yabuki S, Nakaya K
Folia Psychiatr Neurol Jpn. 1976;30(2):93-109. doi: 10.1111/j.1440-1819.1976.tb00115.x.
An immunologic study was made on 170 epileptic patients treated with antiepileptic drugs. The most noteworthy finding was that the serum IgA was decreased in 22 patients, and an IgA deficiency noticed in 12 of them. The blastic transformation rate of lymphocytes in PHA-containing cultures appeared low in seven out of 12 patients. Other findings included decreased serum IgM and IgG in some patients. These abnormalities were not encountered in epileptic patients taking no anti-epileptic drugs. Therefore, they could be considered as the side effects of antiepileptic drugs. In all patients manifesting these abnormalities, diphenylhydantoin was used in common. It was surmised that the above-mentioned immunologic abnormalities caused by anti-epileptic drugs, especially diphenylhydantoin, had resulted from disorders of the antibody producing organs in the bone marrow-thymus-lymphatic system.
对170例接受抗癫痫药物治疗的癫痫患者进行了免疫学研究。最值得注意的发现是，22例患者血清IgA降低，其中12例存在IgA缺乏。12例患者中有7例在含PHA的培养物中淋巴细胞的增殖转化率较低。其他发现包括部分患者血清IgM和IgG降低。未服用抗癫痫药物的癫痫患者未出现这些异常。因此，它们可被视为抗癫痫药物的副作用。在所有出现这些异常的患者中，均共同使用了苯妥英。据推测，抗癫痫药物，尤其是苯妥英引起的上述免疫异常是由骨髓-胸腺-淋巴系统中抗体产生器官的紊乱所致。
