Seager J, Jamison D L, Wilson J, Hayward A R, Soothill J F
Lancet. 1975 Oct 4;2(7936):632-5. doi: 10.1016/s0140-6736(75)90115-4.
In a prospective study of thirty-two children with seizures treated with phenytoin (diphenylhydantoin), five had low levels of serum-IgA before treatment. All of these were among the fifteen who had had febrile convulsions in infancy. IgA levels fell significantly during 6 months treatment in the fourteen patients studied sequentially. Treated children with low serum-IgA had normal numbers of lymphocytes with surface IgA. This suggests that phenytoin causes failure of terminal differentiation of B lymphocytes, and is the first known cause of this, the commonest mechanism of immunoglobulin deficiency.
在一项对32名接受苯妥英钠（二苯乙内酰脲）治疗的癫痫患儿的前瞻性研究中，5名患儿治疗前血清IgA水平较低。所有这些患儿都在15名婴儿期有过热性惊厥的患儿之中。在对14名患儿进行连续6个月的治疗期间，IgA水平显著下降。血清IgA水平低的接受治疗患儿其表面带有IgA的淋巴细胞数量正常。这表明苯妥英钠导致B淋巴细胞终末分化失败，这是已知的首例导致免疫球蛋白缺乏最常见机制的病因。
