Marine Biochemistry Laboratory, Department of Chemistry, Pukyong National University, Busan 608-737, Korea.
Mar Drugs. 2010 Jul 9;8(7):2117-28. doi: 10.3390/md8072117.
Neuronal cells are extremely vulnerable and have a limited capacity for self-repair in response to injury. For those reasons, there is obvious interest in limiting neuronal damage. Mechanisms and strategies used in order to protect against neuronal injury, apoptosis, dysfunction, and degeneration in the central nervous system are recognized as neuroprotection. Neuroprotection could be achieved through several classes of natural and synthetic neuroprotective agents. However, considering the side effects of synthetic neuroprotective agents, the search for natural neuroprotective agents has received great attention. Recently, an increasing number of studies have identified neuroprotective properties of chitosan and its derivatives; however, there are some significant challenges that must be overcome for the success of this approach. Hence, the objective of this review is to discuss neuroprotective properties of chitosan and its derivatives.
神经元细胞极其脆弱，在受到损伤时自我修复的能力有限。出于这些原因，限制神经元损伤的方法引起了广泛关注。为了防止中枢神经系统的神经元损伤、细胞凋亡、功能障碍和退化而采用的机制和策略被认为是神经保护。神经保护可以通过几类天然和合成的神经保护剂来实现。然而，考虑到合成神经保护剂的副作用，对天然神经保护剂的研究受到了极大的关注。最近，越来越多的研究已经确定了壳聚糖及其衍生物的神经保护特性；然而，要成功应用这种方法，还必须克服一些重大挑战。因此，本综述的目的是讨论壳聚糖及其衍生物的神经保护特性。
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