阿密醇 A-C，奥普里尼酰基黄酮类化合物，来源于马达加斯加 Amyris madrensis。
Amyrisins A-C, O-prenylated flavonoids from Amyris madrensis.
机构信息
Department of Pharmacology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, United States.
出版信息
J Nat Prod. 2012 Mar 23;75(3):494-6. doi: 10.1021/np200796e. Epub 2012 Jan 19.
Three new O-prenylated flavonoids, amyrisins A-C (1-3), were isolated from the leaves and twigs of Amyris madrensis, along with the known compound polygamain (4). The structures of 1-3 were elucidated on the basis of the analysis of spectroscopic data interpretation. Amyrisins B (2) and C (3) showed moderate cytotoxicity against PC-3 and DU 145 prostate cancer cells with IC(50) values of 17.5 and 23 μM, respectively, while amyrisin A (1) did not show any cytotoxicity at the highest concentration tested, 50 μM. Polygamain (4) exhibited potent antiproliferative and microtubule-depolymerizing activities.
从远志的叶子和小枝中分离得到三种新的 O-prenylated 类黄酮，分别为 amyrisins A-C（1-3），以及已知化合物 polygamin（4）。根据光谱数据分析，确定了 1-3 的结构。Amyrisins B（2）和 C（3）对前列腺癌细胞 PC-3 和 DU 145 显示出中等的细胞毒性，IC50 值分别为 17.5 和 23 μM，而 amyrisin A（1）在最高测试浓度 50 μM 时没有显示出任何细胞毒性。Polygamain（4）表现出很强的抗增殖和微管解聚活性。
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