Yale School of Public Health, Division of Chronic Disease Epidemiology, New Haven, Connecticut, USA.
Cancer Epidemiol Biomarkers Prev. 2010 Sep;19(9):2220-8. doi: 10.1158/1055-9965.EPI-10-0464. Epub 2010 Aug 17.
Inflammation and immune response have potential prognostic implications for breast cancer survivors. We examined how postdiagnosis diet quality is cross-sectionally related to biomarkers of inflammation and adipose-derived hormones among breast cancer survivors and determined whether physical activity or body size modified any observed associations.
Participants included 746 women diagnosed with stage 0 to IIIA breast cancer. Thirty months after diagnosis, the women completed food frequency questionnaires. We scored diet quality with the Healthy Eating Index (HEI)-2005. Serum concentrations of C-reactive protein (CRP), serum amyloid A, leptin, and adiponectin were measured in fasting 30 mL blood samples. Log biomarker values were regressed on quartiles of HEI-2005 scores in multivariate models, and beta scores were exponentiated and expressed as geometric means within quartiles of HEI-2005 scores.
Women with better versus poor quality postdiagnosis diets, as defined by higher HEI-2005 scores (Q4 versus Q1), had lower concentrations of CRP (1.6 mg/L versus 2.5 mg/L), but no significant difference in concentrations of serum amyloid A, leptin, or adiponectin. Among women not engaging in recreational physical activity after diagnosis, better diet quality was associated with lower CRP concentrations (2.5 mg/L versus 5.0 mg/L), but no association was observed among women engaging in any recreational physical activity (1.4 mg/L versus 1.6 mg/L; P heterogeneity = 0.03).
Among breast cancer survivors, a better-quality diet seems to be associated with lower levels of chronic inflammation.
Lower levels of chronic inflammation have been associated with improved survival after breast cancer.
炎症和免疫反应对乳腺癌幸存者具有潜在的预后意义。我们研究了乳腺癌幸存者在诊断后饮食质量与炎症生物标志物和脂肪衍生激素之间的横断面关系，并确定了身体活动或身体大小是否改变了任何观察到的关联。
参与者包括 746 名被诊断患有 0 期至 IIIA 期乳腺癌的女性。在诊断后 30 个月，女性完成了食物频率问卷。我们使用健康饮食指数（HEI）-2005 对饮食质量进行评分。在空腹 30 毫升血液样本中测量了 C 反应蛋白（CRP）、血清淀粉样蛋白 A、瘦素和脂联素的血清浓度。在多元模型中，将生物标志物的对数值回归到 HEI-2005 评分的四分位数，然后将 beta 分数取幂并表示为 HEI-2005 评分四分位数内的几何平均值。
与较差的诊断后饮食质量（通过较高的 HEI-2005 评分定义为 Q4 与 Q1）相比，饮食质量较好的女性 CRP 浓度较低（1.6mg/L 与 2.5mg/L），但血清淀粉样蛋白 A、瘦素或脂联素的浓度没有显著差异。在诊断后不进行娱乐性身体活动的女性中，更好的饮食质量与 CRP 浓度较低相关（2.5mg/L 与 5.0mg/L），但在进行任何娱乐性身体活动的女性中未观察到相关性（1.4mg/L 与 1.6mg/L；P 异质性=0.03）。
在乳腺癌幸存者中，更好的饮食质量似乎与较低水平的慢性炎症有关。
慢性炎症水平较低与乳腺癌后生存改善有关。
