Department of Medical Nutrition, Graduate School of East-West Medical Science, Kyung Hee University, Seocheon-dong, Giheung-gu, Yongin, Gyeonggi-do, 446-701, Korea.
Inflamm Res. 2010 May;59(5):399-405. doi: 10.1007/s00011-009-0113-8. Epub 2009 Nov 16.
Adipose tissue mass (ATM) is an important source of adipokines. Increases in ATM contribute to chronic low-grade inflammation characterized by high levels of pro-inflammatory cytokines. We investigated the effects of body fat reduction on blood levels of adipokines and pro-inflammatory cytokines in Korean women with BMIs >23 kg/m(2).
A total of 46 healthy women participated in the study. A registered dietician supervised the subjects as they conformed to a program of caloric restriction during a 12-week experimental period. Anthropometric assessments were carried out, and blood levels of lipids, adipokines, and pro-inflammatory cytokines were analyzed at the beginning and the end of the experiment.
Body weight and body fat mass decreased significantly in our subjects after 12 weeks of caloric restriction (p < 0.001). Blood levels of triacylglycerol were significantly reduced in accordance with body fat reduction. However, the other blood lipid parameters were unchanged. Adipokine, leptin, and visfatin levels decreased significantly, while adiponectin increased significantly (p < 0.05). Levels of pro-inflammatory cytokines TNF-alpha and IFN-gamma were significantly reduced (p < 0.05).
Our results indicate that body fat reduction via caloric restriction positively affects the blood levels of adipokines and pro-inflammatory cytokines.
脂肪组织质量（ATM）是脂肪因子的重要来源。ATM 的增加会导致慢性低度炎症，其特征是高水平的促炎细胞因子。我们研究了体脂减少对 BMI>23kg/m(2)的韩国女性血液中脂肪因子和促炎细胞因子水平的影响。
共有 46 名健康女性参与了这项研究。一名注册营养师在 12 周的实验期间监督受试者遵循热量限制计划。在实验开始和结束时进行人体测量评估，并分析血液中的脂质、脂肪因子和促炎细胞因子水平。
经过 12 周的热量限制，我们的研究对象的体重和体脂肪质量显著下降（p<0.001）。血液中三酰甘油水平随着体脂减少而显著降低。然而，其他血脂参数没有变化。脂肪因子瘦素和内脂素水平显著降低，而脂联素水平显著升高（p<0.05）。促炎细胞因子 TNF-α和 IFN-γ水平显著降低（p<0.05）。
我们的结果表明，通过热量限制减少体脂会对血液中脂肪因子和促炎细胞因子水平产生积极影响。
