Department of Psychology, University of Aarhus, Aarhus, Denmark.
Psychosom Med. 2010 Oct;72(8):823-32. doi: 10.1097/PSY.0b013e3181f1d003. Epub 2010 Aug 17.
To quantify the available evidence for the hypothesis that reduced resistance caused by psychological stress may influence the development of clinical disease in those exposed to an infectious agent.
We conducted a systematic review and meta-analysis of 27 prospective studies examining the association between psychological stress and subsequent upper respiratory infection (URI).
The results revealed a significant overall main effect of psychological stress on the risk of developing URI (effect size correlation coefficient, 0.21; 95% confidence interval, 0.15-0.27). Further analyses showed that effect sizes for the association did not vary according to type of stress, how URI was assessed, or whether the studies had controlled for preexposure.
The meta-analytical findings confirmed the hypothesis that psychological stress is associated with increased susceptibility to URI, lending support to an emerging appreciation of the potential importance of psychological factors in infectious disease.
定量评估假设，即心理压力导致的抵抗力下降可能会影响暴露于感染因子的个体临床疾病的发展。
我们对 27 项前瞻性研究进行了系统回顾和荟萃分析，以检验心理压力与随后发生的上呼吸道感染（URI）之间的关联。
结果显示，心理压力对 URI 发病风险存在显著的总体主要影响（效应大小相关系数为 0.21；95%置信区间为 0.15-0.27）。进一步的分析表明，关联的效应大小不因压力类型、URI 的评估方式或研究是否控制了暴露前因素而有所差异。
荟萃分析的结果证实了心理压力与 URI 易感性增加相关的假设，支持了人们对心理因素在传染病中的潜在重要性的日益关注。
