Department of Social and Preventive Epidemiology, School of Public Health, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan.
Psychosom Med. 2010 Oct;72(8):763-8. doi: 10.1097/PSY.0b013e3181f02f15. Epub 2010 Aug 17.
To examine the association between dietary folate, riboflavin, vitamin B-6, and vitamin B-12 and depressive symptoms in a group of adolescents.
This cross-sectional study, conducted in all public junior high schools in Naha City and Nago City, Okinawa, Japan, included 3,067 boys and 3,450 girls aged 12 years to 15 years (52.3% of eligible sample). Dietary intake was assessed using a validated, self-administered diet history questionnaire. Depressive symptoms were defined as present when participants had a Center for Epidemiologic Studies Depression Scale score of ≥16.
The prevalence of depressive symptoms was 22.5% for boys and 31.2% for girls. Folate intake was inversely associated with depressive symptoms in both boys (adjusted odds ratio (OR) [95% confidence interval (CI)] in the highest (compared with the lowest) quintile, 0.60 [0.45, 0.79]; p for trend = .002) and girls (OR [95% CI], 0.61 [0.48, 0.77]; p for trend = <.001). Vitamin B-6 intake was inversely associated with depressive symptoms in both boys (OR [95% CI], 0.73 [0.54, 0.98]; p for trend = .02) and girls (OR [95% CI], 0.72 [0.56, 0.92]; p for trend = .002). Riboflavin intake was inversely associated with depressive symptoms in girls (OR [95% CI], 0.85 [0.67, 1.08]; p for trend = .03), but not in boys. No clear association was seen between vitamin B-12 intake and depressive symptoms in either sex.
This study suggests that higher intake of dietary B vitamins, particularly folate and vitamin B-6, is independently associated with a lower prevalence of depressive symptoms in early adolescence.
在一组青少年中，研究膳食叶酸、核黄素、维生素 B-6 和维生素 B-12 与抑郁症状之间的关系。
这项横断面研究在日本冲绳县那霸市和名护市的所有公立初中进行，共纳入 12 至 15 岁的 3067 名男生和 3450 名女生（占合格样本的 52.3%）。膳食摄入量使用经过验证的自我管理饮食史问卷进行评估。当参与者的中心流行病学研究抑郁量表评分≥16 分时，即定义为存在抑郁症状。
男生的抑郁症状患病率为 22.5%，女生为 31.2%。在男生（最高五分位数与最低五分位数相比，调整后的比值比（OR）[95%置信区间（CI）]为 0.60 [0.45，0.79]；趋势检验 p=0.002）和女生（OR [95%CI]，0.61 [0.48，0.77]；趋势检验 p<.001）中，叶酸摄入量与抑郁症状呈负相关。在男生（OR [95%CI]，0.73 [0.54，0.98]；趋势检验 p=0.02）和女生（OR [95%CI]，0.72 [0.56，0.92]；趋势检验 p=0.002）中，维生素 B-6 摄入量与抑郁症状呈负相关。在女生中，核黄素摄入量与抑郁症状呈负相关（OR [95%CI]，0.85 [0.67，1.08]；趋势检验 p=0.03），但在男生中则无明显关联。在男女两性中，维生素 B-12 摄入量与抑郁症状之间均无明显关联。
本研究表明，较高的膳食 B 族维生素摄入，尤其是叶酸和维生素 B-6，与青少年早期较低的抑郁症状患病率独立相关。
